| Comparative quality tests of two types of sustained release preparation of isosorbide dinitrate. | |
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MedLine Citation:
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PMID: 6484369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two commercial sustained release preparations of isosorbide dinitrate (ISDN), capsules (preparation A) and tablets (preparation B), were tested for content uniformity and dissolution pattern. The deviations in contents of the single doses from the declared content ranged from -7.7% to +9.7% which conformed to the standard (+/- 15%) of the Japanese Pharmacopeia X (JP X). Dissolution tests were performed using the rotating basket method described in JP X. The dissolution medium were No. 1 and 2 solutions (pH 1.2 and 6.8, respectively) specified in JP X disintegration test, and 0.05 M phosphate buffer solutions (pH 3.0 and 5.0). The dissolution patterns of both preparations were independent on the pH of the medium. However, there was a marked difference between the dissolution rates of the two: after 8 hr of the test, the rates of preparation A were 85-89%, but those of preparation B were only 42-50%. From preparation A a somewhat constant release of ISDN continued until the 6 hr. ISDN was determined by the HPLC method. |
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Authors:
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H Noda; M Minemoto; H Furukawa; Y Kanezaki |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of UOEH Volume: 6 ISSN: 0387-821X ISO Abbreviation: J. UOEH Publication Date: 1984 Jun |
Date Detail:
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Created Date: 1984-11-02 Completed Date: 1984-11-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7909645 Medline TA: J UOEH Country: JAPAN |
Other Details:
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Languages: eng Pagination: 141-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Capsules Chromatography, High Pressure Liquid Delayed-Action Preparations Isosorbide Dinitrate / standards* Solubility Tablets |
| Chemical | |
Reg. No./Substance:
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0/Capsules; 0/Delayed-Action Preparations; 0/Tablets; 87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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