| Comparative proteomic analysis between benign and malignant-transformed hydatidiform mole. | |
| | |
MedLine Citation:
|
PMID: 18773628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To explore the differential protein expression between benign/remitting and malignant-transformed hydatidiform mole. STUDY DESIGN: Proteomic analysis was carried out on 7 remitting (including 3 partial moles and 4 complete moles) and 11 malignant-transformed (including 4 partial moles and 7 complete moles) hydatidiform moles. The extracted protein was separated with 2-dimensional electrophoresis, and differentially expressed proteins were analyzed and identified by matrix-assisted desorption/ionization time-of-flight spectrometry (MALDI-TOF-MS). RESULTS: A total of 32 differentially expressed spots were selected. Of these, 17 spots were identified through database searching, mainly involving cytoskeletal protein, stress-associated proteins, apoptosis-associated protein, proteins involved in signal transduction, cell proliferation and differentiation, etc. Of these, 11 might be related to the malignant transformation of hydatidiform mole. CONCLUSION: Seventeen differentially expressed proteins were identified, of which 11 might be associated with malignant transformation of hydatidiform mole. This has laid a foundation for further screening of biomarkers that predict prognosis of hydatidiform mole. |
| | |
Authors:
|
Li Ma; Yang Xiang; Jun Zhao; Fengzhi Feng; Xirun Wan |
Related Documents
:
|
18164778 - Limitations to the comparative proteomic analysis of thrombopoietin producing chinese h... 15800968 - The first two-dimensional reference map of the fission yeast, schizosaccharomyces pombe... 18753468 - Proteomic analysis in lung tissue of smokers and copd patients. 20675398 - Proteins associated with the size and expansion rate of the abdominal aortic aneurysm w... 16341018 - The importance of sequence diversity in the aggregation and evolution of proteins. 21067198 - Magnetic "fishing" assay to screen small-molecule mixtures for modulators of protein-pr... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of reproductive medicine Volume: 53 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 2008 Aug |
Date Detail:
|
Created Date: 2008-09-08 Completed Date: 2009-01-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: United States |
Other Details:
|
Languages: eng Pagination: 623-8 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, People's Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cell Transformation, Neoplastic* Cohort Studies Disease Progression Female Humans Hydatidiform Mole / metabolism*, pathology Middle Aged Neoplasm Proteins / metabolism* Pregnancy Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Tumor Markers, Biological / metabolism* Up-Regulation Uterine Neoplasms / metabolism*, pathology Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Neoplasm Proteins; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An evaluation of FIGO 2000: the first 5 years.
Next Document: Changes of clinical features in hydatidiform mole: analysis of 113 cases.