| Comparative potencies of amphetamine, fenfluramine and related compounds in taste aversion experiments in rats. | |
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MedLine Citation:
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PMID: 597669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1 Rats failed to drink a flavoured solution when its consumption had been followed by injection of amphetamine (conditioned taste aversion).2 There was very little difference between the potencies of (+)- and (-)-amphetamine.3p-Chloromethamphetamine was a more potent aversive agent than methamphetamine.4 Strong taste aversions were also conditioned with other congeners of amphetamine. The rank order of potency was: fenfluramine > chlorphentermine >p-hydroxyamphetamine.5 Cocaine induced only moderate taste aversions, even at high doses.6 Aversive potency did not appear to be correlated with known neurochemical actions of the drugs or with behavioural stimulation, but appeared to be a central action which may have been linked to anorexigenic potency or time course of action. |
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Authors:
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D A Booth; C W Pilcher; G D D'Mello; I P Stolerman |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: British journal of pharmacology Volume: 61 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1977 Dec |
Date Detail:
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Created Date: 1978-03-10 Completed Date: 1978-03-10 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 669-77 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amphetamines
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pharmacology* Animals Avoidance Learning / drug effects Chlorphentermine / pharmacology Cocaine / pharmacology Conditioning (Psychology) / drug effects* Dose-Response Relationship, Drug Fenfluramine / pharmacology Male Methamphetamine / analogs & derivatives, pharmacology Rats Taste / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Amphetamines; 458-24-2/Fenfluramine; 461-78-9/Chlorphentermine; 50-36-2/Cocaine; 537-46-2/Methamphetamine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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