Document Detail


Comparative pharmacology of rat and porcine endothelin in rat aorta and pulmonary artery.
MedLine Citation:
PMID:  2673799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Endothelins are potent vasoactive polypeptides produced by endothelial cells. This study compared the potency and efficacy of porcine and rat endothelin in rat aortic and pulmonary artery rings. We found that porcine endothelin was 25 to 55 times more potent than rat endothelin in both endothelium-intact and -denuded rings. Removal of the endothelium augmented and acetylcholine reduced contraction by either endothelin. We conclude that porcine endothelin is intrinsically more potent than rat endothelin and that the endothelium modulates the contraction of both endothelins.
Authors:
D M Rodman; I F McMurtry; J L Peach; R F O'Brien
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of pharmacology     Volume:  165     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-10-18     Completed Date:  1989-10-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  297-300     Citation Subset:  IM    
Affiliation:
University of Colorado Health Sciences Center, Denver 80262.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Thoracic / drug effects
Endothelins
Male
Muscle Contraction / drug effects
Muscle Relaxation / drug effects
Muscle, Smooth, Vascular / drug effects*
Peptides / pharmacology*
Pulmonary Artery / drug effects
Rats
Rats, Inbred Strains
Species Specificity
Swine
Grant Support
ID/Acronym/Agency:
HL 14985/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Endothelins; 0/Peptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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