| Comparative pharmacokinetics of theophylline and aminophylline in man. | |
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MedLine Citation:
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PMID: 7213528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1 The pharmacokinetics of theophylline and aminophylline was compared after oral administration and intravenous infusion. 2 Theophylline (250 mg) and aminophylline (390 mg) were taken orally by eight healthy volunteers in a randomized cross-over study. 3 In another cross-over study theophylline and aminophylline were administered intravenously to six healthy volunteers at a dose corresponding to 5 mg/kg pure theophylline. 4 The protein binding of the theophylline in serum collected during the intravenous study was studied by ultrafiltration. The serum concentration of theophylline was measured by high pressure liquid chromatography. 5 Almost identical concentration-time curves were found for theophylline and aminophylline in both of the studies. No significant difference was found in the pharmacokinetic parameters or protein binding with the two preparations. |
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Authors:
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A Aslaksen; O M Bakke; T Vigander |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 11 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1981 Mar |
Date Detail:
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Created Date: 1981-06-13 Completed Date: 1981-06-13 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 269-73 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aminophylline / administration & dosage, metabolism* Humans Infusions, Parenteral Kinetics Male Protein Binding Random Allocation Theophylline / administration & dosage, metabolism* |
| Chemical | |
Reg. No./Substance:
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317-34-0/Aminophylline; 58-55-9/Theophylline |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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