| Comparative pharmacokinetics of lovastatin, simvastatin and pravastatin in humans. | |
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MedLine Citation:
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PMID: 1613123 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twelve healthy male volunteers received single market-image 40-mg oral doses of lovastatin and simvastatin (both lactone prodrugs), or pravastatin (a beta-hydroxyacid) at 1 week intervals in a three-way crossover study to quantify HMG-CoA reductase inhibitors in plasma. Multiple plasma samples were collected up to 24 hours after the dose and assayed for active and total HMG-CoA reductase inhibitors. After equal oral doses, higher plasma concentrations of HMG-CoA reductase inhibitory activity after pravastatin than after either lovastatin of simvastatin (2-3 fold greater area under the concentration-time curve) suggest a greater potential availability of pravastatin-related inhibitory activity to peripheral tissues. |
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Authors:
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P J Pentikainen; M Saraheimo; J I Schwartz; R D Amin; M S Schwartz; F Brunner-Ferber; J D Rogers |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical pharmacology Volume: 32 ISSN: 0091-2700 ISO Abbreviation: J Clin Pharmacol Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-07-30 Completed Date: 1992-07-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 136-40 Citation Subset: IM |
Affiliation:
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Third Department of Medicine, University of Helsinki, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Drug Administration Schedule Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors* Lovastatin / analogs & derivatives*, pharmacokinetics* Male Pravastatin / pharmacokinetics* Simvastatin |
| Chemical | |
Reg. No./Substance:
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0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 75330-75-5/Lovastatin; 79902-63-9/Simvastatin; 81093-37-0/Pravastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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