Document Detail

Comparative pharmacokinetics of lovastatin, simvastatin and pravastatin in humans.
MedLine Citation:
PMID:  1613123     Owner:  NLM     Status:  MEDLINE    
Twelve healthy male volunteers received single market-image 40-mg oral doses of lovastatin and simvastatin (both lactone prodrugs), or pravastatin (a beta-hydroxyacid) at 1 week intervals in a three-way crossover study to quantify HMG-CoA reductase inhibitors in plasma. Multiple plasma samples were collected up to 24 hours after the dose and assayed for active and total HMG-CoA reductase inhibitors. After equal oral doses, higher plasma concentrations of HMG-CoA reductase inhibitory activity after pravastatin than after either lovastatin of simvastatin (2-3 fold greater area under the concentration-time curve) suggest a greater potential availability of pravastatin-related inhibitory activity to peripheral tissues.
P J Pentikainen; M Saraheimo; J I Schwartz; R D Amin; M S Schwartz; F Brunner-Ferber; J D Rogers
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  32     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-07-30     Completed Date:  1992-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  136-40     Citation Subset:  IM    
Third Department of Medicine, University of Helsinki, Finland.
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MeSH Terms
Administration, Oral
Drug Administration Schedule
Hydroxymethylglutaryl-CoA Reductase Inhibitors*
Lovastatin / analogs & derivatives*,  pharmacokinetics*
Pravastatin / pharmacokinetics*
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 75330-75-5/Lovastatin; 79902-63-9/Simvastatin; 81093-37-0/Pravastatin

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