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Comparative pharmacokinetics of baicalin, wogonoside, baicalein and wogonin in plasma after oral administration of pure baicalin, radix scutellariae and scutellariae-paeoniae couple extracts in normal and ulcerative colitis rats.
MedLine Citation:
PMID:  24250647     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to investigate the pharmacokinetic profiles of baicalin, wogonoside, baicalein and wogonin after oral administration of pure baicalin, Radix scutellariae and Scutellariae-Paeoniae couple extracts were administered and the pharmacokinetics profiles were compared between normal and ulcerative colitis rats. The plasma concentrations of the four flavonoids were determined by using a simple and rapid high-performance liquid chromatography method. All the rats were divided randomly into two groups (ulcerative colitis and normal groups). Each group contained three subgroups: pure baicalin, Radix scutellariae and Scutellariae-Paeoniae couple extracts subgroup. Each group received oral administration of pure baicalin, Radix Scutellariae and Scutellariae-Paeoniae couple extracts at the same dose of 200 mg/kg baicalin. The results showed that wogonoside, possibily as a methylated product of baicalin, was found in plasma after oral administration of pure baicalin or formulas to rats. Baicalin and wogonoside demonstrated bimodal phenomenon. Baicalin and wogonoside in Scutellariae-Paeoniae couple extract had shown better absorption than which in pure baicalin and Radix Scutellariae extract. Whether oral administration of pure baicalin, Radix Scutellariae or Scutellariae-Paeoniae couple extracts, ulcerative colitis rats showed better absorption than normal rats. For example AUC (0-t) of baicalin were: (41.46 ± 0.62), (59.12 ± 6.42) and (104.87 ± 0.86) (μg/mL)·h in UC groups vs (17.77 ± 0.66), (28.04 ± 4.06) and (49.01 ± 4.61) (μg/mL)·h in normal groups, respectively. The pharmacokinetics properties of the four flavonoids differed between ulcerative colitis and normal rats, including AUC ( 0-t ) and Cmax (p < 0.05).
Authors:
Zhen-Qiu Zhang; Wei Liua; Li Zhuang; Jing Wang; Shuai Zhang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Iranian journal of pharmaceutical research : IJPR     Volume:  12     ISSN:  1735-0328     ISO Abbreviation:  Iran J Pharm Res     Publication Date:  2013  
Date Detail:
Created Date:  2013-11-19     Completed Date:  2013-11-19     Revised Date:  2013-11-22    
Medline Journal Info:
Nlm Unique ID:  101208407     Medline TA:  Iran J Pharm Res     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  399-409     Citation Subset:  -    
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