Document Detail

Comparative pharmacokinetic study of oral and rectal formulations of artesunic acid in healthy volunteers.
MedLine Citation:
PMID:  9754985     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: A single cross-over, comparative pharmacokinetic study of oral and rectal formulations of 200 mg artesunic acid in 12 healthy Malaysian volunteers is reported. METHODS: Plasma concentrations of artesunic acid and dihydroartemisinin were determined simultaneously by HPLC with electrochemical detection. The test drug was well tolerated and no undesirable adverse effects were observed. RESULTS: Comparison of pharmacokinetic parameters of artesunic acid after oral and rectal administration showed statistically significant differences in t(max) and AUC, with no changes for Cmax and t1/2. As for dihydroartemisinin, differences were observed for t(max) and Cmax but not for AUC. CONCLUSION: There appear to be pharmacokinetic differences between oral and rectal modes of administration. The significance of these findings should be explored in malaria patients before appropriate therapeutic regimens are devised.
V Navaratnam; S M Mansor; M N Mordi; A Akbar; M N Abdullah
Related Documents :
7767865 - Effect of oral administration of ursodeoxycholic acid on rat hepatic and intestinal udp...
3200265 - Effects of ursodeoxycholic acid and aspirin on the formation of lithogenic bile and gal...
1563325 - Effect of intraduodenal administration of 23-methyl-udca diastereoisomers on bile flow ...
16924055 - Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomi...
23396555 - Nucleic acid-mesoporous silica nanoparticle conjugates for keypad lock security operation.
1706705 - Specificity of attenuation control in the ilvgmeda operon of escherichia coli k-12.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  54     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-12-01     Completed Date:  1998-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  411-4     Citation Subset:  IM    
Centre for Drug Research, Universiti Sains Malaysia, Penang.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Oral
Administration, Rectal
Antimalarials / administration & dosage,  blood,  pharmacokinetics*
Bicyclo Compounds, Heterocyclic / administration & dosage,  blood,  pharmacokinetics*
Cross-Over Studies
Sesquiterpenes / blood,  pharmacokinetics
Succinates / administration & dosage,  blood,  pharmacokinetics*
Reg. No./Substance:
0/Antimalarials; 0/Artemisinins; 0/Bicyclo Compounds, Heterocyclic; 0/Sesquiterpenes; 0/Succinates; 71939-50-9/dihydroquinghaosu; 88495-63-0/artesunic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Safety and pharmacokinetics of a single oral dose of amisulpride in healthy elderly volunteers.
Next Document:  Pharmacokinetics of nimustine, methotrexate, and cytosine arabinoside during cerebrospinal fluid per...