Document Detail


Comparative pharmacokinetic study of oral and rectal formulations of artesunic acid in healthy volunteers.
MedLine Citation:
PMID:  9754985     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: A single cross-over, comparative pharmacokinetic study of oral and rectal formulations of 200 mg artesunic acid in 12 healthy Malaysian volunteers is reported. METHODS: Plasma concentrations of artesunic acid and dihydroartemisinin were determined simultaneously by HPLC with electrochemical detection. The test drug was well tolerated and no undesirable adverse effects were observed. RESULTS: Comparison of pharmacokinetic parameters of artesunic acid after oral and rectal administration showed statistically significant differences in t(max) and AUC, with no changes for Cmax and t1/2. As for dihydroartemisinin, differences were observed for t(max) and Cmax but not for AUC. CONCLUSION: There appear to be pharmacokinetic differences between oral and rectal modes of administration. The significance of these findings should be explored in malaria patients before appropriate therapeutic regimens are devised.
Authors:
V Navaratnam; S M Mansor; M N Mordi; A Akbar; M N Abdullah
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  54     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-12-01     Completed Date:  1998-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  411-4     Citation Subset:  IM    
Affiliation:
Centre for Drug Research, Universiti Sains Malaysia, Penang.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Administration, Rectal
Adult
Antimalarials / administration & dosage,  blood,  pharmacokinetics*
Artemisinins*
Bicyclo Compounds, Heterocyclic / administration & dosage,  blood,  pharmacokinetics*
Cross-Over Studies
Humans
Male
Sesquiterpenes / blood,  pharmacokinetics
Succinates / administration & dosage,  blood,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Antimalarials; 0/Artemisinins; 0/Bicyclo Compounds, Heterocyclic; 0/Sesquiterpenes; 0/Succinates; 71939-50-9/dihydroquinghaosu; 88495-63-0/artesunic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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