Document Detail


Comparative peripheral and coronary haemodynamic effects of rimiterol and isoprenaline.
MedLine Citation:
PMID:  28135     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Rimiterol and isoprenaline produced significant dose-related increases in cardiac output. 2. These changes in cardiac output were accompanied by increases in heart rate and myocardial oxygen consumption which were similar for each drug and dose-related. 3. Isoprenaline in contrast with rimiterol produced direct coronary vasodilation, i.e. coronary vasodilation in excess of that required to meet increases in myocardial oxygen demands. 4. It is suggested that the beta-adrenergic receptors in the human coronary vasculature are mainly of the beta1 type. 5. Rimiterol, because it does not produce direct coronary vasodilation may be preferable to isoprenaline in the treatment of low-cardiac output syndrome where there is regional myocardial ischaemia, since it would be less likely to produce a "coronary steal" effect.
Authors:
J D Stephens; R P Hayward; H Ead; L Adams; R A Spurrell
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  6     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-10-27     Completed Date:  1978-10-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  163-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Catechols / pharmacology*
Coronary Circulation / drug effects
Hemodynamics / drug effects*
Humans
Isoproterenol / pharmacology*
Male
Middle Aged
Myocardium / metabolism
Oxygen Consumption / drug effects
Piperidines / pharmacology*
Regional Blood Flow / drug effects
Chemical
Reg. No./Substance:
0/Catechols; 0/Piperidines; 32953-89-2/rimiterol; 7683-59-2/Isoproterenol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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