| Comparative peripheral and coronary haemodynamic effects of rimiterol and isoprenaline. | |
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MedLine Citation:
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PMID: 28135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Rimiterol and isoprenaline produced significant dose-related increases in cardiac output. 2. These changes in cardiac output were accompanied by increases in heart rate and myocardial oxygen consumption which were similar for each drug and dose-related. 3. Isoprenaline in contrast with rimiterol produced direct coronary vasodilation, i.e. coronary vasodilation in excess of that required to meet increases in myocardial oxygen demands. 4. It is suggested that the beta-adrenergic receptors in the human coronary vasculature are mainly of the beta1 type. 5. Rimiterol, because it does not produce direct coronary vasodilation may be preferable to isoprenaline in the treatment of low-cardiac output syndrome where there is regional myocardial ischaemia, since it would be less likely to produce a "coronary steal" effect. |
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Authors:
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J D Stephens; R P Hayward; H Ead; L Adams; R A Spurrell |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 6 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1978 Aug |
Date Detail:
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Created Date: 1978-10-27 Completed Date: 1978-10-27 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 163-70 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Catechols / pharmacology* Coronary Circulation / drug effects Hemodynamics / drug effects* Humans Isoproterenol / pharmacology* Male Middle Aged Myocardium / metabolism Oxygen Consumption / drug effects Piperidines / pharmacology* Regional Blood Flow / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Catechols; 0/Piperidines; 32953-89-2/rimiterol; 7683-59-2/Isoproterenol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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