| Comparative ototoxicity of kanamycin A and kanamycin B in the guinea pig. | |
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MedLine Citation:
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PMID: 3564930 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has previously been shown that simple compounds with multiple amine groups are ototoxic, the degree of ototoxicity depending on the number of amine groups in the molecule. The relationship between the number of amino groups and ototoxicity in aminoglycoside was studied using kanamycin A and kanamycin B, which contain 4 and 5 amino groups respectively. Forty-five pigmented guinea pigs were injected intratympanically with 0.1 ml of different concentrations of kanamycin A and kanamycin B. The animals were sacrificed 4 days after injection and the organ of Corti was studied by scanning electron microscopy. It was found that on an equimolar basis, kanamycin B (with 5 amino groups) is more cochleotoxic than kanamycin A (with 4 amino groups). The greater cochleotoxic potential of kanamycin B may be explained by the higher cationic nature of the molecule due to protonation of the amino--NH2 groups at physiological pH, resulting in a greater affinity between the drug and the cell membrane. |
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Authors:
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M W Yung |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta oto-laryngologica Volume: 103 ISSN: 0001-6489 ISO Abbreviation: Acta Otolaryngol. Publication Date: 1987 Jan-Feb |
Date Detail:
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Created Date: 1987-05-07 Completed Date: 1987-05-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370354 Medline TA: Acta Otolaryngol Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 73-80 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cations / physiology Cochlea / drug effects* Dose-Response Relationship, Drug Ear, Middle / drug effects Guinea Pigs Kanamycin / administration & dosage, analogs & derivatives*, toxicity* Microscopy, Electron, Scanning Organ of Corti / drug effects, pathology*, ultrastructure Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Cations; 4696-76-8/bekanamycin; 59-01-8/Kanamycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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