Document Detail


Comparative ontogenesis of brain tryptamine, serotonin, and tryptophan.
MedLine Citation:
PMID:  2578059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pattern of ontogenetic development of tryptophan (TP), tryptamine (T), indole-3-acetic acid (IAA), 5-hydroxytryptamine (5-HT; serotonin), and 5-hydroxyindole-3-acetic acid (5-HIAA) in the brains of rats aged 1-45 days is presented. Analysis of the five components in each brain allows the calculation of the acid/amine and amine/amino acid ratios. These metabolic indexes are a useful tool to study and compare the metabolic origins and fates of both amines. The ontogenetic patterns of TP, T, and IAA are very similar, especially during the first week postpartum. The highest and lowest levels found for T were 2.2 ng/g and 0.1 ng/g at the 1st and 5th day, respectively. The temporal relationship between the T/TP and IAA/T ratios suggests the existence of mechanisms protecting T against monoamine oxidase (MAO) which develop in parallel to synaptogenesis. Significant correlations were found between TP and IAA during the whole period studied and between TP and T during the first week after birth. The 5-HT peak found during the first postpartum week could be due to a non-neuronal pool of 5-HT protected against MAO and possibly contained in mast cells. Preliminary determinations on leptomeningeal membranes suggest the existence of such a pool.
Authors:
F Artigas; C Suñol; J M Tusell; E Martínez; E Gelpí
Related Documents :
17208479 - Non-enzymatic lipid peroxidation of microsomes and mitochondria from liver, heart and b...
9178429 - The delta 5-3 beta-hydroxy steroid acyl transferase activities in tissues of the male r...
431889 - Metabolic and secretory processes in nerve-endings isolated from post-mortem brain.
15737439 - Analysis of cholinergic markers, biogenic amines, and amino acids in the cns of two app...
1581019 - Diurnal rhythms in rat brain large neutral amino acids (lnaas), monoamines and monoamin...
6779509 - Membrane lipids in the pathogenesis of brain edema: phospholipids and arachidonic acid,...
2897459 - Compatibility of intravenous fat emulsions with prodrug amino acids.
2857639 - Stimulation of somatostatin release from median eminence tissue incubated in vitro by t...
2513579 - Zinc uptake by isolated rat enterocytes: effect of low molecular weight ligands.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  44     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-01-23     Completed Date:  1985-01-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  31-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Brain / growth & development*
Brain Chemistry
Chromatography, High Pressure Liquid
Fluorometry
Hydroxyindoleacetic Acid / analysis
Indoleacetic Acids / analysis
Male
Rats
Rats, Inbred Strains
Serotonin / analysis*
Tryptamines / analysis*
Tryptophan / analysis*
Chemical
Reg. No./Substance:
0/Indoleacetic Acids; 0/Tryptamines; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid; 61-54-1/tryptamine; 73-22-3/Tryptophan; 87-51-4/indoleacetic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Protein turnover in brain of the rat fetus.
Next Document:  Reversible dihydropyridine isothiocyanate binding to brain calcium channels.