Document Detail

Comparative ontogenesis of brain tryptamine, serotonin, and tryptophan.
MedLine Citation:
PMID:  2578059     Owner:  NLM     Status:  MEDLINE    
The pattern of ontogenetic development of tryptophan (TP), tryptamine (T), indole-3-acetic acid (IAA), 5-hydroxytryptamine (5-HT; serotonin), and 5-hydroxyindole-3-acetic acid (5-HIAA) in the brains of rats aged 1-45 days is presented. Analysis of the five components in each brain allows the calculation of the acid/amine and amine/amino acid ratios. These metabolic indexes are a useful tool to study and compare the metabolic origins and fates of both amines. The ontogenetic patterns of TP, T, and IAA are very similar, especially during the first week postpartum. The highest and lowest levels found for T were 2.2 ng/g and 0.1 ng/g at the 1st and 5th day, respectively. The temporal relationship between the T/TP and IAA/T ratios suggests the existence of mechanisms protecting T against monoamine oxidase (MAO) which develop in parallel to synaptogenesis. Significant correlations were found between TP and IAA during the whole period studied and between TP and T during the first week after birth. The 5-HT peak found during the first postpartum week could be due to a non-neuronal pool of 5-HT protected against MAO and possibly contained in mast cells. Preliminary determinations on leptomeningeal membranes suggest the existence of such a pool.
F Artigas; C Suñol; J M Tusell; E Martínez; E Gelpí
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  44     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-01-23     Completed Date:  1985-01-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  31-7     Citation Subset:  IM    
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MeSH Terms
Brain / growth & development*
Brain Chemistry
Chromatography, High Pressure Liquid
Hydroxyindoleacetic Acid / analysis
Indoleacetic Acids / analysis
Rats, Inbred Strains
Serotonin / analysis*
Tryptamines / analysis*
Tryptophan / analysis*
Reg. No./Substance:
0/Indoleacetic Acids; 0/Tryptamines; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid; 61-54-1/tryptamine; 73-22-3/Tryptophan; 87-51-4/indoleacetic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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