Document Detail

Comparative morphometric study of eruptive PUVA-induced and chronic sun-induced lentigines of the skin.
MedLine Citation:
PMID:  2025370     Owner:  NLM     Status:  MEDLINE    
Computerized image analysis was used to compare lentigines (brown freckle-like cutaneous spots) induced by treatment with psoralens and ultraviolet light A (PUVA-induced lentigines) with those induced by solar exposure (actinic lentigines). For these conditions, which appear to be distinctive clinically and histologically, the number, size and shape of the macules were analyzed, revealing significant differences in the two latter parameters. This indicates that UV irradiations of different wave lengths act differently on melanocytes and/or on the interrelation between melanocytes and keratinocytes. The overall effect is much more self-limited in PUVA lentigines than in actinic lentigines, suggesting that the pathophysiology of these lesions is probably different.
A Nikkels; T Ben Mosbah; C Piérard-Franchimont; M de la Brassinne; G E Piérard
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology     Volume:  13     ISSN:  0884-6812     ISO Abbreviation:  Anal. Quant. Cytol. Histol.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-06-12     Completed Date:  1991-06-12     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  8506819     Medline TA:  Anal Quant Cytol Histol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  23-6     Citation Subset:  IM    
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MeSH Terms
Image Processing, Computer-Assisted
Lentigo / chemically induced,  etiology*,  pathology
PUVA Therapy / adverse effects*
Psoriasis / drug therapy
Sunlight / adverse effects*
Ultraviolet Rays / adverse effects*

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