Document Detail

Comparative metabolism and pharmacokinetics of seven neonicotinoid insecticides in spinach.
MedLine Citation:
PMID:  18922014     Owner:  NLM     Status:  MEDLINE    
The metabolism of seven commercial neonicotinoid insecticides was compared in spinach seedlings (Spinacia oleracea) using HPLC-DAD and LC-MSD to analyze the large number and great variety of metabolites. The parent neonicotinoid levels in the foliage following hydroponic treatment varied from differences in uptake and persistence. The metabolic reactions included nitro reduction, cyano hydrolysis, demethylation, sulfoxidation, imidazolidine and thiazolidine hydroxylation and olefin formation, oxadiazine hydroxylation and ring opening, and chloropyridinyl dechlorination. The identified phase I plant metabolites were generally the same as those in mammals, but the phase II metabolites differed in the conjugating moieties. Novel plant metabolites were various neonicotinoid-derived O- and N-glucosides and -gentiobiosides and nine amino acid conjugates of chloropyridinylcarboxylic acid. Metabolites known to be active on nicotinic acetylcholine receptors included the desnitro- and descyanoguanidines and olefin derivatives. The findings highlight both metabolites common to several neonicotinoids and those that are compound specific.
Kevin A Ford; John E Casida
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-10-16
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  56     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-06     Completed Date:  2008-12-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10168-75     Citation Subset:  IM    
Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720-3112, USA.
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MeSH Terms
Guanidines / metabolism*,  pharmacokinetics*
Insecticides / metabolism*,  pharmacokinetics*
Nitro Compounds / metabolism*,  pharmacokinetics*
Pyridines / metabolism*,  pharmacokinetics*
Spinacia oleracea / drug effects,  metabolism*
Thiazoles / metabolism*,  pharmacokinetics*
Grant Support
Reg. No./Substance:
0/Guanidines; 0/Insecticides; 0/Nitro Compounds; 0/Pyridines; 0/Thiazoles

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