Document Detail


Comparative long-term vasoactive effects of atenolol and carteolol on the properties of the small and large arteries of the upper extremities in human essential hypertension.
MedLine Citation:
PMID:  2689046     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The long-term effects of selective (atenolol) and nonselective (carteolol) beta-blockers on brachial artery diameter velocity and flow and on vascular resistance (pulsed Doppler) were compared in two groups of 10 hypertensive patients at respective daily doses of 100 and 20 mg. The drugs decreased mean blood pressure (p less than 0.01) with similar magnitude, although systolic blood pressure was decreased more by atenolol than by carteolol (p less than 0.05). Heart rate was decreased by atenolol (p less than 0.01) but was unchanged by carteolol. The drugs did not change brachial circulation when the hand circulation was present. During hand exclusion (wrist occlusion) comparison from baseline showed that atenolol decreased velocity and flow (p less than 0.01, p less than 0.05) and increased resistance (p less than 0.05), whereas carteolol decreased resistance (p less than 0.05); after 3 months of treatment, velocity and flow were higher (p less than 0.01, p less than 0.001) and resistance was lower (p less than 0.01) with carteolol than with atenolol. Thus, hand exclusion demonstrated opposite drug effects on arterioles--dilation for carteolol and constriction for atenolol.
Authors:
I P Merli; J Levenson; V Filitti; A Simon
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  46     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-01-26     Completed Date:  1990-01-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  686-92     Citation Subset:  AIM; IM    
Affiliation:
Diagnostic Center, Hôpital Broussais, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Arteries / drug effects*
Atenolol / pharmacology*,  therapeutic use
Blood Flow Velocity
Blood Pressure / drug effects
Brachial Artery / drug effects
Carteolol / pharmacology*,  therapeutic use
Double-Blind Method
Female
Heart Rate / drug effects
Humans
Hypertension / drug therapy*,  physiopathology
Male
Middle Aged
Propanolamines / pharmacology*
Randomized Controlled Trials as Topic
Ultrasonics
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Propanolamines; 29122-68-7/Atenolol; 51781-06-7/Carteolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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