Document Detail


Comparative long-term efficacy and safety of drug-eluting stent versus coronary artery bypass grafting in ostial left main coronary artery disease: Analysis of the MAIN-COMPARE Registry.
MedLine Citation:
PMID:  22234884     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: To date, drug-eluting stent (DES) implantation has not been compared with coronary artery bypass grafting (CABG) for ostial left main coronary artery (LMCA) lesions. Methods: Of the 263 patients in the MAIN-COMPARE registry with ostial LMCA stenosis, 123 were treated with percutaneous coronary intervention (PCI) with DES and 140 with CABG. We compared their 5-year overall survival, composite outcomes of death, Q-wave myocardial infarction (MI) or stroke, and target vessel revascularization (TVR) rates. Results: Unadjusted analysis showed no significant differences between CABG and DES in overall survival rates (95% confidence interval (CI) for hazard ratio (HR): 0.44 to 1.77, P = 0.71), composite outcomes (death, Q-wave MI, or stroke)-free survival rates (95% CI for HR: 0.41-1.63, P = 0.56), and TVR-free survival rates (95% CI for HR: 0.79-5.03, P = 0.14). Multivariate adjusted Cox regression analysis also showed no significant between-group differences in TVR (95% CI for HR: 0.52-3.79, P = 0.49), death (95% CI for HR: 0.79-2.82, P = 0.22) and the composite of death, Q-wave MI, or stroke (95% CI for HR: 0.65-2.57, P = 0.46). These results were sustained after propensity score adjustment and propensity score matching analysis. Conclusions: DES implantation for ostial LMCA lesions showed similar 5-year outcomes of death, major adverse events, and TVR compared with CABG. Although meticulous adjustments decreased baseline difference between the two treatments, the absence of statistical significance could be attributable to the size of the study sample and hidden bias. © 2012 Wiley Periodicals, Inc.
Authors:
Seung-Whan Lee; Sung-Hwan Kim; Seon-Ok Kim; Seungbong Han; Young-Hak Kim; Duk-Woo Park; Soo-Jin Kang; Cheol Whan Lee; Seong-Wook Park; Seung-Jung Park
Related Documents :
3155954 - Echocardiographic features of impaired left ventricular diastolic function in chagas's ...
20412274 - Rosiglitazone, but not pioglitazone, improves myocardial systolic function in type 2 di...
11092654 - Pseudonormal and restrictive filling patterns predict left ventricular dilation and car...
2956104 - A study of the correlation between doppler and cross-sectional echocardiography in the ...
6657654 - Myocardial perfusion and left ventricular performance during long and short haemodialys...
3733264 - Myocardial infarction and subtotal obstruction of the anterior descending coronary arte...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-10
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  -     ISSN:  1522-726X     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Department of Cardiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Early dosing and efficacy of triptans in acute migraine treatment: The TEMPO study.
Next Document:  Chiral Mercaptoacetamides Display Enantioselective Inhibition of Histone Deacetylase?6 and Exhibit N...