Document Detail


Comparative kinetics of phenobarbital after administration of the acid and the propylhexedrine salt (barbexaclone).
MedLine Citation:
PMID:  3709618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The kinetics of phenobarbital (PB) was compared after oral administration of equivalent doses of the drug as the acid or the propylhexedrine salt (barbexaclone) to 7 normal volunteers. The absorption and elimination parameters were very similar. It was concluded that propylhexedrine did not affect the serum kinetics of PB given as barbexaclone.
Authors:
E Perucca; R Grimaldi; G Ruberto; C Gelmi; F Trimarchi; A Crema
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  29     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1986  
Date Detail:
Created Date:  1986-07-24     Completed Date:  1986-07-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  729-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Half-Life
Humans
Kinetics
Male
Phenobarbital / analogs & derivatives*,  blood,  metabolism*
Chemical
Reg. No./Substance:
4388-82-3/barbexaclone; 50-06-6/Phenobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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