Document Detail


Comparative investigations of human and porcine somatotropin.
MedLine Citation:
PMID:  6115810     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human and porcine somatotropin were compared by different methods. Both hormones show biological activity in the Greenspan assay. Molecular masses, N- and C-terminal amino acids as well as the chromatographic patterns on ion exchange cellulose at room temperature are identical. Chromatography in the cold results in different behaviour of the two hormones. Polyacrylamide gel electrophoresis and electrofocusing also show characteristic differences. The quantitative amino acid analyses of the two hormones are different. The N-terminal amino acid sequences estimated up to position 20 show identity only in 13 positions.
Authors:
M Schleyer; T Trah; I Schleyer; E Kley
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hoppe-Seyler's Zeitschrift für physiologische Chemie     Volume:  362     ISSN:  0018-4888     ISO Abbreviation:  Hoppe-Seyler's Z. Physiol. Chem.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-11-18     Completed Date:  1981-11-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985060R     Medline TA:  Hoppe Seylers Z Physiol Chem     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  875-81     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Amino Acids / analysis
Animals
Biological Assay
Cartilage / drug effects
Humans
Molecular Weight
Peptide Fragments / analysis
Rats
Somatostatin* / isolation & purification,  pharmacology
Species Specificity
Swine
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Peptide Fragments; 51110-01-1/Somatostatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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