Document Detail


Comparative investigation of sphingoid bases and fatty acids in ceramides and sphingomyelins from human ovarian malignant tumors and normal ovary.
MedLine Citation:
PMID:  9795275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fatty acid and sphingoid base compositions of ceramides and sphingomyelins were investigated in malignant tumors and normal tissue of human ovaries. It has been established that fatty acid compositions of ceramide and sphingomyelin isolated from one tissue are significantly different: the predominant acids are oleic (18:1) in ceramide and palmitic (16:0) in sphingomyelin, which contains much more other saturated acids. These differences are characteristic of both normal and tumor tissues. Sphingoid base compositions of ceramide and sphingomyelin in normal tissue are identical: the major component is sphingenine (over 96%), while ceramides from tumors contain, in addition to sphingenine, a significant amount of sphinganine. In sphingomyelins from tumors, sphinganine content is significantly lower than in ceramides and depends on the type of tumor.
Authors:
S N Rylova; O G Somova; E V Dyatlovitskaya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemistry. Biokhimii͡a     Volume:  63     ISSN:  0006-2979     ISO Abbreviation:  Biochemistry Mosc.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1999-01-25     Completed Date:  1999-01-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376536     Medline TA:  Biochemistry (Mosc)     Country:  RUSSIA    
Other Details:
Languages:  eng     Pagination:  1057-60     Citation Subset:  IM    
Affiliation:
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117871, Russia.
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MeSH Terms
Descriptor/Qualifier:
Ceramides / chemistry*
Fatty Acids / analysis*,  chemistry
Female
Granulosa Cell Tumor / chemistry
Humans
Oleic Acid / analysis
Ovarian Neoplasms / chemistry*
Ovary / chemistry*
Palmitic Acid / analysis
Sphingomyelins / chemistry*
Sphingosine / analogs & derivatives,  analysis
Chemical
Reg. No./Substance:
0/Ceramides; 0/Fatty Acids; 0/Sphingomyelins; 112-80-1/Oleic Acid; 123-78-4/Sphingosine; 57-10-3/Palmitic Acid; 764-22-7/safingol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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