Document Detail

Comparative in vitro studies with 4-quinolone antimicrobials.
MedLine Citation:
PMID:  2941259     Owner:  NLM     Status:  MEDLINE    
The minimal inhibitory concentrations (MICs) of nalidixic acid, pipemidic acid, cinoxacin, oxolinic acid, flumequine, pefloxacin, acrosoxacin, amifloxacin, norfloxacin, enoxacin, ofloxacin and ciprofloxacin were determined for a range of clinical isolates. MICs were determined using an agar dilution technique in Mueller-Hinton agar supplemented with 10% lysed horse blood. The inoculum used was approximately 10(4) colony forming units, contained in 10 microliters Mueller-Hinton broth, which was applied to the agar plates using a multipoint inoculator. Following inoculation, plates were incubated in conditions appropriate for the organisms under investigation. The MIC of each antimicrobial for each isolate examined was determined as the lowest concentration of the antimicrobial which completely inhibited growth of the inoculum. The minimum concentrations required to inhibit the growth of 50% (MIC50) and 90% (MIC90) of the organisms examined were also determined. All of the more recently synthesised 4-quinolones showed considerably greater activity than the parent compounds, nalidixic acid, pipemidic acid and cinoxacin, against the range of organisms used in this study. Ciprofloxacin and ofloxacin were the two most active of the 4-quinolones examined.
D Felmingham; M D O'Hare; M J Robbins; R A Wall; A H Williams; A W Cremer; G L Ridgway; R N Grüneberg
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Drugs under experimental and clinical research     Volume:  11     ISSN:  0378-6501     ISO Abbreviation:  Drugs Exp Clin Res     Publication Date:  1985  
Date Detail:
Created Date:  1986-08-08     Completed Date:  1986-08-08     Revised Date:  2013-04-24    
Medline Journal Info:
Nlm Unique ID:  7802135     Medline TA:  Drugs Exp Clin Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  317-29     Citation Subset:  IM    
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MeSH Terms
Anti-Infective Agents*
Bacteria / drug effects
Cinoxacin / pharmacology
Microbial Sensitivity Tests
Nalidixic Acid / analogs & derivatives*,  pharmacology
Naphthyridines / pharmacology
Norfloxacin / analogs & derivatives,  pharmacology
Oxazines / pharmacology
Oxolinic Acid / pharmacology
Pipemidic Acid / pharmacology
Quinolines / pharmacology
Quinolizines / pharmacology
Reg. No./Substance:
0/4-Quinolones; 0/Anti-Infective Agents; 0/Fluoroquinolones; 0/Naphthyridines; 0/Oxazines; 0/Quinolines; 0/Quinolizines; 0/Quinolones; 14698-29-4/Oxolinic Acid; 28657-80-9/Cinoxacin; 389-08-2/Nalidixic Acid; 3Y1OT3J4NW/rosoxacin; 51940-44-4/Pipemidic Acid; 5TU5227KYQ/amifloxacin; 70458-92-3/Pefloxacin; 70458-96-7/Norfloxacin; 74011-58-8/Enoxacin; 82419-36-1/Ofloxacin; 85721-33-1/Ciprofloxacin; UVG8VSP2SJ/flumequine

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