Document Detail


Comparative in vitro cytotoxicity study of carbon nanotubes and titania nanostructures on human lung epithelial cells.
MedLine Citation:
PMID:  21601355     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The aim of this study is to assess in vitro cytotoxic effects of titania nanostructures and carbon nanotubes (CNTs) by exposing A549 lung epithelial cell line to these materials. Titania nanotubes (TiNTs) were grown by hydrothermal treatment of TiO(2) nanoparticles, followed by annealing them at 400°C. The titania nanostructures obtained on annealing (mixture of nanotubes and nanorods) were hollow and open ended, containing 3-5 layers of titania sheets, with an internal diameter ∼3-5nm and external diameter ∼8-10nm, and a specific surface area of 265m(2)/g. As-supplied single walled (SWCNTs) and microwave plasma enhanced chemical vapour deposition (MPCVD) grown multi walled carbon nanotubes (MWCNTs) were used in this study. The lengths and diameters of the SWCNTs were 5-10nm and 0.5-3nm respectively. The lengths and diameters of the MWCNTs were 25-30μm and 10-30nm respectively. The cell viability was evaluated using the MTT (3-(4,-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium) assay. No significant cytotoxic effects of titania nanostructures were observed over a period of a week of testing time, while the presence of CNTs in some cases demonstrated significant cytotoxic effects. Finally, possible reason of cytotoxicity is discussed in the light of microstructures of materials.
Authors:
S Wadhwa; C Rea; P O'Hare; A Mathur; S S Roy; P S M Dunlop; J A Byrne; G Burke; B Meenan; J A McLaughlin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-16
Journal Detail:
Title:  Journal of hazardous materials     Volume:  -     ISSN:  1873-3336     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-5-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422688     Medline TA:  J Hazard Mater     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Nanotechnology and Integrated Bio-Engineering center, School of Engineering, University of Ulster, Jordanstown, Co Antrim, BT37 0QB, Northern Ireland UK.
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