Document Detail


Comparative in vitro activity of ciprofloxacin and five other quinoline derivatives against gram-negative isolates.
MedLine Citation:
PMID:  2941260     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 375 Gram-negative bacterial strains were isolated from midstream urine specimens of the same number of patients affected by urinary tract infections. All bacteria were identified by standard bacteriological methods and their susceptibility to six quinoline derivatives (ciprofloxacin, cinoxacin, norfloxacin, oxolinic acid, pipemidic acid, nalidixic acid) was studied by determining the MICs and MBCs for each compound using a miniaturized dilution broth method in microtitre plates and twofold dilutions of each drug from 256 to 0.12 mcg/ml. Ciprofloxacin, a new quinoline carboxylic acid compound structurally related to nalidixic acid, showed a much higher antibacterial activity against all bacterial strains under examination, including Pseudomonas, than the other compounds, except for norfloxacin. The MIC90 and MBC90 of ciprofloxacin never exceeded 1 mcg/ml with any of the bacterial species; and MBC/MIC ratios were very low, which represents an important clinical advantage. Only norfloxacin showed comparable effectiveness. No bacterial strain showed resistance to the drug and the MIC90 and MBC90 never exceeded 8 mcg/ml.
Authors:
D Galante; C Pennucci; S Esposito; D Barba
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Drugs under experimental and clinical research     Volume:  11     ISSN:  0378-6501     ISO Abbreviation:  Drugs Exp Clin Res     Publication Date:  1985  
Date Detail:
Created Date:  1986-08-08     Completed Date:  1986-08-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802135     Medline TA:  Drugs Exp Clin Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  331-4     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Bacteriuria / microbiology
Cinoxacin / pharmacology
Ciprofloxacin
Gram-Negative Bacteria / drug effects*
Humans
Microbial Sensitivity Tests
Nalidixic Acid / pharmacology
Norfloxacin / pharmacology
Oxolinic Acid / pharmacology
Pipemidic Acid / pharmacology
Quinolines / pharmacology*
Chemical
Reg. No./Substance:
0/Quinolines; 14698-29-4/Oxolinic Acid; 28657-80-9/Cinoxacin; 389-08-2/Nalidixic Acid; 51940-44-4/Pipemidic Acid; 70458-96-7/Norfloxacin; 85721-33-1/Ciprofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparative in vitro studies with 4-quinolone antimicrobials.
Next Document:  Influence of pH and human urine on the antibacterial activity of ciprofloxacin, norfloxacin and oflo...