| Comparative in-vitro activity of Sch 34343 for a wide spectrum of clinically significant anaerobic bacteria. | |
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MedLine Citation:
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PMID: 4030546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One hundred and fifty strains of anaerobic bacteria including 45 bacteroides, 19 fusobacteria, 41 cocci, 34 clostridia, and 11 Gram-positive non-sporeforming rods were tested by agar dilution for their susceptibilities to cefoxitin, cefuroxime, latamoxef (moxalactam), penicillin G, chloramphenicol, clindamycin, metronidazole and Sch 34343. Excluding the 34 clostridia, 115 of the 116 remaining strains were inhibited by less than or equal to 1 mg/l of Sch 34343. One isolate of Bacteroides fragilis required 32 mg/l for inhibition. All of the 34 clostridia were inhibited by less than or equal to 8 mg/l of Sch 34343: 14 isolates of Clostridium difficile had an MIC50 and an MIC90 of 4 mg/l, whereas the remaining 20 species of clostridia had an MIC50 of 0.125 mg/l and an MIC90 of 2 mg/l. On a weight basis, Sch 34343 was generally more active than any of the seven other antimicrobial agents tested. |
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Authors:
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C L Wells; T D Wilkins |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of antimicrobial chemotherapy Volume: 15 Suppl C ISSN: 0305-7453 ISO Abbreviation: J. Antimicrob. Chemother. Publication Date: 1985 Jun |
Date Detail:
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Created Date: 1985-09-30 Completed Date: 1985-09-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7513617 Medline TA: J Antimicrob Chemother Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 177-82 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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pharmacology* Bacteria, Anaerobic / drug effects* Bacterial Infections / microbiology Bacteroides / drug effects Clostridium / drug effects Drug Resistance, Microbial Fusobacterium / drug effects Humans Lactams* Microbial Sensitivity Tests Peptococcus / drug effects Streptococcus / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Lactams; 95415-91-1/Sch 34343 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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