| Comparative impact of scintigraphic parameters and B-type natriuretic peptide for the prediction of major cardiac events in the QGS-prognostic value in the elderly (Q-PROVE) study. | |
| | |
MedLine Citation:
|
PMID: 19638709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Although B-type natriuretic peptide (BNP) has emerged as an important predictor for cardiac events, its effect on scintigraphic parameters is unknown. METHODS AND RESULTS: The Q-PROVE study is a multicenter study to evaluate the prognostic value of ECG-gated SPECT in 175 Japanese elderly patients. In addition, BNP was assessed in 102 patients. Outcome assessment included cardiac events and noncardiac deaths. Twelve elderly patients (12%) had increased BNP >130 pg/ml. The summed stress score (SSS) was greater in patients with increased BNP than in those with normal BNP. Kaplan-Meier survival estimation indicated event-free survival rates at 3 years of 83%, 78%, 88%, 80%, respectively, in patients with BNP >130 pg/ml, SSS >or=7, summed difference score (SDS) >or=2, and dilated end-diastolic volume (EDV), but 98%, 98%, 100%, 94% in those with BNP <or=130 pg/ml, SSS <7, SDS <2 and normal EDV (P=0.006, P=0.005, P=0.0008, P=0.01). Multivariate analysis demonstrated that an SDS was the only independent predictor for subsequent cardiac events (hazard ratio =4.0, P=0.04). CONCLUSIONS: Although BNP may have similar prognostic value to gated SPECT volumetric measurements in elderly patients with known or suspected coronary artery disease, myocardial ischemia as documented by SPECT is still indispensable for detecting high-risk patients compared with BNP alone. |
| | |
Authors:
|
Yuko Igarashi; Taishiro Chikamori; Satoshi Hida; Tadashi Nagao; Hirokazu Tanaka; Yasuhiro Usui; Tsuguhisa Hatano; Takayuki Morishima; Hidefumi Yanagisawa; Akira Yamashina |
Related Documents
:
|
18443269 - Different cut-off values of quantitative d-dimer methods to predict the risk of venous ... 17884449 - Adipose tissue, serum adipokines, and ghrelin in patients with ankylosing spondylitis. 18633599 - Sclerosing injections to treat midportion achilles tendinosis: a randomised controlled ... 17873489 - Accuracy of n-terminal probrain natriuretic peptide to predict mortality or detect acut... 18495689 - Prognostic value of right ventricular dysfunction in patients with haemodynamically sta... 16320329 - Cyclooxygenase- and lipoxygenase-derived eicosanoids in bronchoalveolar lavage fluid fr... 21774839 - Bone turnover is adequately suppressed in osteoporotic patients treated with bisphospho... 20012079 - Serum protein profiling of smear-positive and smear-negative pulmonary tuberculosis usi... 18355709 - Dealing with the difficult trauma and reconstructive surgery patient. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2009-07-28 |
Journal Detail:
|
Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 73 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2009 Sep |
Date Detail:
|
Created Date: 2009-08-26 Completed Date: 2009-11-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
|
Languages: eng Pagination: 1655-60 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Tokyo Medical University, Tokyo, Japan. yuko50@tokyo-med.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Aged Aged, 80 and over Biological Markers / blood Coronary Artery Disease / blood, complications, diagnosis*, mortality, radionuclide imaging Disease-Free Survival Electrocardiography Humans Japan / epidemiology Kaplan-Meiers Estimate Myocardial Ischemia / blood, etiology*, mortality, radionuclide imaging Natriuretic Peptide, Brain / blood* Predictive Value of Tests Proportional Hazards Models Risk Assessment Risk Factors Time Factors Tomography, Emission-Computed, Single-Photon* Up-Regulation |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Waist circumference and waist-to-height ratio as predictors of cardiovascular disease risk in Korean...
Next Document: Comparison of endocardial and epicardial lesion size following large-tip and extra-large-tip transca...