| Comparative imipenem treatment of Staphylococcus aureus endocarditis in the rat. | |
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MedLine Citation:
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PMID: 6583198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy of imipenem alone or in association with gentamicin against Staphylococcus aureus experimental endocarditis was compared to the efficacy of cloxacillin alone or in association with gentamicin. Parenteral treatment was started 24 h after intravenous bacterial challenge of rats with catheter-induced aortic valve vegetations. The cloxacillin MIC and MBC for Staph. aureus were 0.125 and 32 mg/l and the imipenem MIC and MBC 0.008 and 8 mg/l, respectively. In-vitro killing curves showed a synergistic effect between cloxacillin and gentamicin, and an additive effect between imipenem and gentamicin. Only large doses of cloxacillin (400 mg/kg tid) (producing serum levels above those obtained after intravenous injection of 2 g in man) achieved results comparable to those of imipenem 80 mg/kg tid (producing serum levels similar to those obtained after an intravenous dose of 750 mg in man) in reducing the bacterial numbers in vegetations after 3 and 5 days of treatment. There was a significantly greater reduction of bacterial numbers in vegetations after treatment with the association of cloxacillin and gentamicin than with cloxacillin alone. In contrast, the addition of gentamicin to imipenem did not improve significantly the results of treatment with imipenem alone, but imipenem alone was as good as the combination cloxacillin and gentamicin after 5 days of treatment. We conclude that imipenem is a highly bactericidal drug in this animal model, worth considering for clinical trials in the treatment of Staph. aureus infections. |
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Authors:
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J D Baumgartner; M P Glauser |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of antimicrobial chemotherapy Volume: 12 Suppl D ISSN: 0305-7453 ISO Abbreviation: J. Antimicrob. Chemother. Publication Date: 1983 Dec |
Date Detail:
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Created Date: 1984-04-11 Completed Date: 1984-04-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7513617 Medline TA: J Antimicrob Chemother Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 79-87 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cloxacillin / therapeutic use* Drug Therapy, Combination Endocarditis, Bacterial / drug therapy*, microbiology Female Gentamicins / therapeutic use Imipenem Rats Rats, Inbred Strains Staphylococcal Infections / drug therapy* Thienamycins / blood, therapeutic use* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Gentamicins; 0/Thienamycins; 61-72-3/Cloxacillin; 74431-23-5/Imipenem |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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