| Comparative hepatic proteome analysis between lean and obese rats fed a high fat diet reveals existence of gender differences. | |
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MedLine Citation:
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PMID: 22140079 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Gender differences in obesity stem from metabolic and hormonal differences between sexes and contribute to differences between women and men in health risks attributable to obesity. We hypothesized that liver may be an ideal target for evaluation of gender differences in obesity development in response to a high fat diet (HFD). Therefore, to test this hypothesis, we performed global proteome analysis in the liver of lean and obese rats of both genders who were fed a HFD through 2-DE combined with MALDI-TOF-MS. When rats were exposed to HFD, male rats gained more body weight with increased values of plasma biochemical parameters than female rats. Image analysis and further statistical analysis of a 2-DE protein map allowed for detection and identification of 34 proteins that were significantly modulated in a gender-dependent manner. We found 19 proteins showing identical gender-different regulation in both normal diet (ND) and HFD. Five proteins also showed clear gender differences in both ND and HFD; however, their regulation modes in HFD were opposite to those in ND. Of particular interest, 10 proteins showed gender differences only in either ND or HFD rats. Present proteomic insight into gender-dimorphic protein modulation in liver would aid in improvement of gender awareness in the health care system and in implementation of evidence-based gender specific clinical recommendations. |
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Authors:
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Xia Wang; Jung-Won Choi; Tae Seok Oh; Duk Kwon Choi; Rajib Mukherjee; Hao Liu; Jong Won Yun |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-5 |
Journal Detail:
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Title: Proteomics Volume: - ISSN: 1615-9861 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101092707 Medline TA: Proteomics Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk 712-714, Republic of Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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