| Comparative hepatic microsomal biotransformation of selected PBDEs, including decabromodiphenyl ether, and decabromodiphenyl ethane flame retardants in arctic marine-feeding mammals. | |
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MedLine Citation:
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PMID: 21437940 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The present study assessed and compared the oxidative and reductive biotransformation of brominated flame retardants, including established polybrominated diphenyl ethers (PBDEs) and emerging decabromodiphenyl ethane (DBDPE) using an in vitro system based on liver microsomes in liver microsomes from various arctic marine-feeding mammals: polar bear (Ursus maritimus), beluga whale (Delphinapterus leucas), and ringed seal (Pusa hispida), and in laboratory rat as a mammalian model species. Greater depletion of fully brominated BDE209 (14 - 25% of 30 pmol) and DBDPE (44 - 74% of 90 pmol) occurred in individuals from all species relative to depletion of lower brominated PBDEs (BDEs 99, 100, and 154; 0 - 3% of 30 pmol). No evidence of simply debrominated metabolites was observed. Investigation of phenolic metabolites in rat and polar bear revealed formation of two phenolic, likely multiply-debrominated, DBDPE metabolites in polar bear and one phenolic BDE154 metabolite in polar bear and rat microsomes. For BDE209 and DBDPE, observed metabolite concentrations were low to non-detectable, despite substantial parent depletion. These findings suggested possible underestimation of the ecosystem burden of total-BDE209, as well as (BDE209 and its transformation products), and a need for research to identify (and characterize the persistence and toxicity of) major BDE209 metabolites. There may be a similar cause for concern regarding DBDPE, given similarities of physico-chemical and environmental behavior to BDE209, current evidence of biotransformation, and increasing use of DBDPE as a replacement for BDE209. Environ. Toxicol. Chem. © 2011 SETAC. |
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Authors:
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Melissa A McKinney; Rune Dietz; Christian Sonne; Sylvain De Guise; Karl Skirnisson; Karl Karlsson; Egill Steingrímsson; Robert J Letcher |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-24 |
Journal Detail:
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Title: Environmental toxicology and chemistry / SETAC Volume: - ISSN: 1552-8618 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8308958 Medline TA: Environ Toxicol Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 SETAC. |
Affiliation:
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Carleton University, Ottawa, Ontario K1S 5B6, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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