Document Detail

Comparative hemodynamic effects of labetalol and hydralazine in the treatment of postoperative hypertension.
MedLine Citation:
PMID:  2627388     Owner:  NLM     Status:  MEDLINE    
The antihypertensive efficacy and safety of IV labetalol were evaluated and compared with the efficacy and safety of IV hydralazine in the treatment of postoperative hypertension. Twenty patients undergoing major noncardiac surgery were entered into the study. Patients were randomized and treated for postoperative hypertension with either labetalol (n = 10) or hydralazine (n = 10). Labetalol and hydralazine both produced significant reductions in arterial blood pressure (p less than 0.001) within 10 minutes, which lasted at least 2 hours. In addition, labetalol produced a significant reduction in the heart rate and rate-pressure product without creating any adverse effects. In contrast, hydralazine produced significant sinus tachycardia requiring IV propranolol in three patients, two of whom developed transient ST segment depression. These results indicate that labetalol is safe and effective for the control of postoperative hypertension, especially in those patients who are least able to tolerate tachycardia.
I Dimich; R Lingham; G Gabrielson; P P Singh; J A Kaplan
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of clinical anesthesia     Volume:  1     ISSN:  0952-8180     ISO Abbreviation:  J Clin Anesth     Publication Date:  1989  
Date Detail:
Created Date:  1990-04-26     Completed Date:  1990-04-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8812166     Medline TA:  J Clin Anesth     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  201-6     Citation Subset:  IM    
Department of Anesthesiology, Mount Sinai School of Medicine, (CUNY), New York 10029-6574.
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MeSH Terms
Hydralazine / administration & dosage,  therapeutic use*
Hypertension / drug therapy*,  physiopathology
Labetalol / administration & dosage,  therapeutic use*
Middle Aged
Postoperative Complications / drug therapy*
Tachycardia / drug therapy*,  physiopathology
Reg. No./Substance:
36894-69-6/Labetalol; 86-54-4/Hydralazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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