Document Detail

Comparative haemodynamic effects of lidocaine, mexiletine, and disopyramide.
MedLine Citation:
PMID:  6202976     Owner:  NLM     Status:  MEDLINE    
The effect of intravenous boluses of lidocaine (5 mg/kg), mexiletine (3.5 mg/kg), and disopyramide (5 mg/kg) on mean arterial pressure (MAP), heart rate (HR), cardiac output (CO), total peripheral resistance, left ventricular end-diastolic pressure, and peak rate of change of left ventricular pressure (peak LV dP/dt) were assessed in the conscious rabbit. Plasma levels for the three drugs corresponded to the human therapeutic range 3 min after administration. All three drugs had negative inotropic effects and reduced HR. Lidocaine reduced peak LV dP/dt by 26%, mexiletine by 41%, and disopyramide by 53%. The three drugs had quite different effects on CO as a result of differences in their actions on peripheral blood vessels: disopyramide caused a 21% fall in CO, associated with a significant vasoconstriction; mexiletine did not lower CO, as it caused a substantial vasodilation; and lidocaine did not produce any substantial change in either CO or vascular resistance. Cardiac autonomic blockade did not alter these changes. These results confirm that disopyramide has a marked cardiodepressant effect, and demonstrate that, although lidocaine depresses myocardial contractility in the conscious rabbit, it has little effect on other haemodynamic parameters. The experiments also show that mexiletine is a more profound negative inotrope than lidocaine, but that, as it produces a significant fall in MAP and thus a reduction in afterload, the CO is maintained.
J Beltrame; P E Aylward; R J McRitchie; J P Chalmers
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  6     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:    1984 May-Jun
Date Detail:
Created Date:  1984-07-19     Completed Date:  1984-07-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  483-90     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Cardiac Output / drug effects
Disopyramide / blood,  pharmacology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Lidocaine / blood,  pharmacology*
Mexiletine / blood,  pharmacology*
Propylamines / pharmacology*
Vascular Resistance / drug effects
Reg. No./Substance:
0/Propylamines; 137-58-6/Lidocaine; 31828-71-4/Mexiletine; 3737-09-5/Disopyramide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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