| Comparative haemodynamic effects of lidocaine, mexiletine, and disopyramide. | |
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MedLine Citation:
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PMID: 6202976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of intravenous boluses of lidocaine (5 mg/kg), mexiletine (3.5 mg/kg), and disopyramide (5 mg/kg) on mean arterial pressure (MAP), heart rate (HR), cardiac output (CO), total peripheral resistance, left ventricular end-diastolic pressure, and peak rate of change of left ventricular pressure (peak LV dP/dt) were assessed in the conscious rabbit. Plasma levels for the three drugs corresponded to the human therapeutic range 3 min after administration. All three drugs had negative inotropic effects and reduced HR. Lidocaine reduced peak LV dP/dt by 26%, mexiletine by 41%, and disopyramide by 53%. The three drugs had quite different effects on CO as a result of differences in their actions on peripheral blood vessels: disopyramide caused a 21% fall in CO, associated with a significant vasoconstriction; mexiletine did not lower CO, as it caused a substantial vasodilation; and lidocaine did not produce any substantial change in either CO or vascular resistance. Cardiac autonomic blockade did not alter these changes. These results confirm that disopyramide has a marked cardiodepressant effect, and demonstrate that, although lidocaine depresses myocardial contractility in the conscious rabbit, it has little effect on other haemodynamic parameters. The experiments also show that mexiletine is a more profound negative inotrope than lidocaine, but that, as it produces a significant fall in MAP and thus a reduction in afterload, the CO is maintained. |
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Authors:
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J Beltrame; P E Aylward; R J McRitchie; J P Chalmers |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 6 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1984 May-Jun |
Date Detail:
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Created Date: 1984-07-19 Completed Date: 1984-07-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 483-90 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Cardiac Output / drug effects Disopyramide / blood, pharmacology* Female Heart Rate / drug effects Hemodynamics / drug effects* Lidocaine / blood, pharmacology* Male Mexiletine / blood, pharmacology* Propylamines / pharmacology* Rabbits Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Propylamines; 137-58-6/Lidocaine; 31828-71-4/Mexiletine; 3737-09-5/Disopyramide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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