Document Detail

Comparative haemodynamic effects of glucagon and isoprenaline in the early postoperative period in cardiac surgery.
MedLine Citation:
PMID:  1209206     Owner:  NLM     Status:  MEDLINE    
In order to study the haemodynamic effects of isoprenaline and glucagon in the immediate postoperative period, 16 patients who had single or multiple valve replacement or coronary artery bypass grafts were investigated. Measurements of cardiac index, stroke index, heart rate, arterial and right atrial mean pressures were made either before, during, or after the administration of both drugs. With the doses used, the inotropic effects of both drugs are similar, while the chronotropic action is statistically higher during isoprenaline infusion than after glucagon administration. This fact explains the greater increase in cardiac index after isoprenaline administration. Mean arterial pressure shows no significant changes after either drug, while right atrial mean pressure decreases significantly. Peripheral vascular resistance remained mostly constant. The activity of glucagon injected as a single bolus seems to be maximal 10 to 15 minutes after the injection and dissipates about 30 minutes later. The ideal dose of isoprenaline is between 0.8 and 2 mug/min. Within this range, the inotropic effect is maximal and the chronotropic and bathmotropic effects are limited. Above 2 mug/min, cardiac index and stroke index decrease, and arrhythmias become more frequent.
M Goenen; P Jaumin; A Raveau; J Tremouroux
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Scandinavian journal of thoracic and cardiovascular surgery     Volume:  9     ISSN:  0036-5580     ISO Abbreviation:  Scand J Thorac Cardiovasc Surg     Publication Date:  1975  
Date Detail:
Created Date:  1976-03-15     Completed Date:  1976-03-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0121343     Medline TA:  Scand J Thorac Cardiovasc Surg     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  206-11     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Cardiac Output / drug effects
Cardiac Surgical Procedures*
Dose-Response Relationship, Drug
Glucagon / administration & dosage,  pharmacology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Isoproterenol / administration & dosage,  pharmacology*
Middle Aged
Time Factors
Vascular Resistance / drug effects
Reg. No./Substance:
7683-59-2/Isoproterenol; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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