| Comparative genotoxicity of the herbicides Roundup, Stomp and Reglone in plant and mammalian test systems. | |
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MedLine Citation:
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PMID: 16998229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The genotoxicities of the herbicides Roundup (glyphosate), Stomp (pendimethaline) and Reglone (diquat), were compared in plant (Crepis capillaris L.) and mouse bone marrow test systems using chromosomal aberrations and micronuclei. Roundup did not induce chromosomal aberrations or micronuclei in either test system. Reglone also did not induce chromosomal aberrations in either test system; however, it increased micronucleus frequency in both plant cells and mouse bone marrow polychromatic erythrocytes (PCEs). The responses of the two test systems to Stomp were quite different. Stomp did not induce chromosomal aberrations in the plant cells, but increased their incidence in mouse cells; Stomp increased the frequency of micronuclei in both test systems. The induction of micronuclei in plant cells may have been due to the spindle-destroying effect of the herbicide, since all concentrations of Stomp produced C-mitoses. The increased chromosomal aberration frequency in mouse bone marrow cells observed at later sampling times after administration of Stomp into animals suggests that the induction of aberrations may be due to biosynthesis of genotoxic metabolites. This conclusion was supported by the coincidence between the frequencies of chromosomal aberrations and of micronucleated PCEs in mouse cells. These data indicate that plant and animal assays are differentially responsive to some pesticides, and these differences may be due to metabolism and their responses to mitotic spindle disruption. |
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Authors:
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Boyan D Dimitrov; Polina G Gadeva; Donka K Benova; Maria V Bineva |
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Publication Detail:
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Type: Journal Article Date: 2006-09-23 |
Journal Detail:
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Title: Mutagenesis Volume: 21 ISSN: 0267-8357 ISO Abbreviation: Mutagenesis Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-31 Completed Date: 2007-01-04 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8707812 Medline TA: Mutagenesis Country: England |
Other Details:
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Languages: eng Pagination: 375-82 Citation Subset: IM |
Affiliation:
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Institute of Genetics, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria. dimitrow_b@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aniline Compounds
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toxicity Animals Bone Marrow / drug effects* Chromosome Aberrations Diquat / toxicity Erythroid Precursor Cells / drug effects* Glycine / analogs & derivatives, toxicity Herbicides / toxicity* Mice Mice, Inbred C57BL Micronucleus Tests Mitosis / drug effects* Mutagenicity Tests Mutagens / toxicity* Plant Roots / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Aniline Compounds; 0/Herbicides; 0/Mutagens; 1071-83-6/glyphosate; 2764-72-9/Diquat; 40487-42-1/pendimethalin; 56-40-6/Glycine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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