| Comparative genotoxicity of halogenated acetic acids found in drinking water. | |
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MedLine Citation:
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PMID: 9379909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three short-term assays (SOS chromotest, Ames fluctuation test and newt micronucleus test) were performed to detect the genotoxic activity of organohalides, compounds likely to be found in chlorinated and/or ozonated drinking water: monochloro-, dichloro- and trichloroacetic acids and monobromo-, dibromo- and tribromoacetic acids. With the SOS chromotest, only three of the chemicals studied (dichloroacetic acid, dibromo- and tribromoacetic acids) were found to induce primary DNA damage in Escherichia coli PQ 37. In the Ames fluctuation test, all the compounds except monochloroacetic acid showed mutagenic activity in Salmonella typhimurium strain TA100. In these two in vitro tests, a good correlation between increasing number of substituents and decreasing mutagenicity was observed. Namely, the toxicity of brominated and chlorinated acetic acids decreased when the number of substituents increased. The newt micronucleus test detected a weak clastogenic effect on the peripheral blood erythrocytes of Pleurodeles waltl larvae for trichloroacetic acid only. |
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Authors:
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S Giller; F Le Curieux; F Erb; D Marzin |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Mutagenesis Volume: 12 ISSN: 0267-8357 ISO Abbreviation: Mutagenesis Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-11-10 Completed Date: 1997-11-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8707812 Medline TA: Mutagenesis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 321-8 Citation Subset: IM |
Affiliation:
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Laboratory of Genetic Toxicology, Pasteur Institute of Lille, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acids
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toxicity* Animals DNA Damage Dichloroacetate / toxicity* Escherichia coli / drug effects, genetics Micronucleus Tests Mutagenicity Tests Mutagens / toxicity* SOS Response (Genetics) / drug effects Salamandridae Salmonella typhimurium / drug effects Trichloroacetic Acid / analogs & derivatives*, toxicity Water Supply* |
| Chemical | |
Reg. No./Substance:
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0/Acetic Acids; 0/Mutagens; 13425-80-4/Dichloroacetate; 631-64-1/dibromoacetic acid; 68-10-0/bromoacetate; 75-96-7/tribromoacetic acid; 76-03-9/Trichloroacetic Acid; 79-11-8/chloroacetic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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