Document Detail


Comparative genomics of Anopheles gambiae and Drosophila melanogaster.
MedLine Citation:
PMID:  15177694     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A sequence analysis of the genomes of Anopheles gambiae and Drosophila melanogaster reveals that Anopheles DNA is more heterogeneous and GC-richer than Drosophila DNA. The gene concentration across the Anopheles genome is characterized by low levels in the GC-poor part of the genome and a 3-fold increase in the GC-richest part; this gene density gradient is approximately half that of Drosophila. GC levels of introns and flanking sequences are correlated with GC(3) values (GC levels of third codon positions) of the corresponding genes with slopes much lower than unity; in other words, most introns and intergenic sequences are less GC-rich than the corresponding GC(3) values. These findings, which describe a compositional shift within Diptera, is of interest because of their parallels in the well studied major shift in vertebrates.
Authors:
Kamel Jabbari; Giorgio Bernardi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Gene     Volume:  333     ISSN:  0378-1119     ISO Abbreviation:  Gene     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-06-04     Completed Date:  2004-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706761     Medline TA:  Gene     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  183-6     Citation Subset:  IM    
Affiliation:
Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, F-75005 Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anopheles / genetics*
Base Composition / genetics
Codon / genetics
DNA / genetics
Drosophila melanogaster / genetics*
Genes, Insect / genetics
Genome
Genomics*
Introns / genetics
Chemical
Reg. No./Substance:
0/Codon; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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