Document Detail


Comparative genomic hybridization analysis on male breast cancer.
MedLine Citation:
PMID:  16353155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The spectrum of genetic alterations in primary male breast cancer is not well established. We analyzed chromosomal imbalances in 39 tumor samples from primary male breast cancer by comparative genomic hybridization (CGH) and correlated CGH findings with clinicopathological factors. Chromosomal gains were most frequent at 1q (46%), 8q (46%), 16p (36%), 17q (36%), Xq (28%), 20q (26%) and Xp (18%). Losses were most commonly observed at 8p (36%), 16q (28%), 13q (28%), 6q (18%), 11q (18%) and 22q (18%). Gains at 16p, 20q and Xq and losses at 13q correlated significantly with higher degree of cytogenetic complexity. Significant associations with clinicopathological factors were observed for +8q and -16q with larger tumor size and -16q with lower proliferative activity and lower grade of malignancy. A comparison with reported CGH data from female breast cancer showed a similar pattern of chromosomal imbalances, including +1q, -8p, +8q, -13q, +16p, -16q, +17q and +20q. Our results indicate that male breast cancer shares a common pattern of imbalances with female breast cancer, suggesting that similar genetic events may underlie the development and progression of male and female breast cancer.
Authors:
Christian Rudlowski; Hans-Jürgen Schulten; Mariola Monika Golas; Bjoern Sander; Roland Barwing; Jens-Ekkehard Palandt; Bettina Schlehe; Rüdiger Lindenfelser; Roland Moll; Torsten Liersch; Volker Schumpelick; Bastian Gunawan; László Füzesi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  118     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-03-06     Completed Date:  2006-05-22     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2455-60     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 Wiley-Liss, Inc.
Affiliation:
Department of Obstetrics and Gynecology, University of Bonn, Germany. rudlowski@t-online.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Breast Neoplasms, Male / genetics*
Chromosome Aberrations*
Disease Progression
Humans
Immunohistochemistry
Male
Nucleic Acid Hybridization*

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