| Comparative gastrointestinal enzyme activity and activation of the promutagen 2,6-dinitrotoluene in male CD-1 mice and male Fischer 344 rats. | |
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MedLine Citation:
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PMID: 2354414 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Comparative intestinal nitroreductase, azo reductase, beta-glucuronidase, dechlorinase and dehydrochlorinase activities in young male Fischer 344 rats and young male CD-1 mice were measured in vitro while the comparative biotransformation of 2,6-dinitrotoluene to mutagenic metabolites was determined in vivo. The mice, which exhibit a high spontaneous incidence of hepatomas, had markedly greater nitroreductase activity and metabolized significantly more 2,6-dinitrotoluene to mutagenic metabolites than did Fischer 344 rats, which show a low incidence of liver tumors. Results of this study indicate that species differences in the incidence of hepatomas may be influenced by microbial flora and/or the biotransformation of xenobiotics in the G.I. tract. |
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Authors:
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R W Chadwick; S E George; J Chang; M J Kohan; J P Dekker; J E Long; M C Duffy |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Cancer letters Volume: 52 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1990 Jun |
Date Detail:
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Created Date: 1990-07-20 Completed Date: 1990-07-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 13-9 Citation Subset: IM |
Affiliation:
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Health Effects Research Laboratory Environmental Research Center, U.S. Environmental Protection Agency Research, Triangle Park, N.C. 27711. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biotransformation Dinitrobenzenes / metabolism* Glucuronidase / metabolism Intestines / enzymology* Liver Neoplasms, Experimental / chemically induced Lyases / metabolism Male Mice Mice, Inbred Strains Nitrobenzenes / metabolism* Nitroreductases / metabolism Rats Rats, Inbred F344 |
| Chemical | |
Reg. No./Substance:
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0/Dinitrobenzenes; 0/Nitrobenzenes; 606-20-2/2,6-dinitrotoluene; EC 1.7.-/Nitroreductases; EC 3.2.1.31/Glucuronidase; EC 4.-/Lyases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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