Document Detail

Comparative flavonoids contents of selected herbs and associations of their radical scavenging activity with antiproliferative actions in V79-4 cells.
MedLine Citation:
PMID:  19723177     Owner:  NLM     Status:  MEDLINE    
To elucidate the health benefit of herbal teas on the cytotoxicity induced by H(2)O(2) in V79-4 cells, herbal extracts and its flavonoids were tested using lactate dehydrogenase release and determining intracellular reactive oxygen species generation and antioxidant activity with superoxide radical scavenging assay. Significant decrease in cell viability was observed on V79-4 cells treated with H(2)O(2) (1 mM), while herbal extracts and its flavonoids including catechin and epigallocatechin gallate prevented the LDH release from H(2)O(2) cytotoxicity. Total catechin contents of green tea (65.6 mg/g of dry matter) were significantly higher than other herbal teas (35.8 to 1.2 mg/g of DM). The relative concentration of the 4 major tea catechins ranked EGCG > EGC > EC > C. Green tea exhibited the lowest IC(50) values (2 g fresh herb/100 mL) of superoxide radical scavenging activity among the tested herbal tea, which indicates powerful antioxidant activity in O(2)(*-) radicals scavenging, followed by black tea, dandelion, hawthorn, rose hip, chamomile.
Kyung Mi Yoo; In-Kyeong Hwang; BoKyung Moon
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of food science     Volume:  74     ISSN:  1750-3841     ISO Abbreviation:  J. Food Sci.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-09-02     Completed Date:  2010-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0014052     Medline TA:  J Food Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  C419-25     Citation Subset:  IM    
Dept. of Food and Nutrition, Research Inst. of Human Ecology, Seoul Natl. Univ., Seoul, South Korea.
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MeSH Terms
Antioxidants / analysis,  metabolism
Catechin / analogs & derivatives,  analysis,  pharmacology
Cell Line
Cell Proliferation / drug effects*
Cell Survival / drug effects
Flavonoids / analysis*,  pharmacology*
Free Radical Scavengers / metabolism*
Hydrogen Peroxide / toxicity
Inhibitory Concentration 50
Lipid Peroxidation / drug effects
Plant Extracts / chemistry,  pharmacology
Plant Leaves / chemistry,  metabolism
Plants, Medicinal / chemistry*,  metabolism
Reactive Oxygen Species / metabolism
Species Specificity
Tea / chemistry*,  metabolism
Reg. No./Substance:
0/Antioxidants; 0/Flavonoids; 0/Free Radical Scavengers; 0/Plant Extracts; 0/Reactive Oxygen Species; 0/Tea; 154-23-4/Catechin; 7722-84-1/Hydrogen Peroxide

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