| Comparative flavonoids contents of selected herbs and associations of their radical scavenging activity with antiproliferative actions in V79-4 cells. | |
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MedLine Citation:
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PMID: 19723177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To elucidate the health benefit of herbal teas on the cytotoxicity induced by H(2)O(2) in V79-4 cells, herbal extracts and its flavonoids were tested using lactate dehydrogenase release and determining intracellular reactive oxygen species generation and antioxidant activity with superoxide radical scavenging assay. Significant decrease in cell viability was observed on V79-4 cells treated with H(2)O(2) (1 mM), while herbal extracts and its flavonoids including catechin and epigallocatechin gallate prevented the LDH release from H(2)O(2) cytotoxicity. Total catechin contents of green tea (65.6 mg/g of dry matter) were significantly higher than other herbal teas (35.8 to 1.2 mg/g of DM). The relative concentration of the 4 major tea catechins ranked EGCG > EGC > EC > C. Green tea exhibited the lowest IC(50) values (2 g fresh herb/100 mL) of superoxide radical scavenging activity among the tested herbal tea, which indicates powerful antioxidant activity in O(2)(*-) radicals scavenging, followed by black tea, dandelion, hawthorn, rose hip, chamomile. |
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Authors:
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Kyung Mi Yoo; In-Kyeong Hwang; BoKyung Moon |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of food science Volume: 74 ISSN: 1750-3841 ISO Abbreviation: J. Food Sci. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-09-02 Completed Date: 2010-01-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0014052 Medline TA: J Food Sci Country: United States |
Other Details:
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Languages: eng Pagination: C419-25 Citation Subset: IM |
Affiliation:
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Dept. of Food and Nutrition, Research Inst. of Human Ecology, Seoul Natl. Univ., Seoul, South Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / analysis, metabolism Catechin / analogs & derivatives, analysis, pharmacology Cell Line Cell Proliferation / drug effects* Cell Survival / drug effects Cricetinae Cricetulus Cytoprotection Flavonoids / analysis*, pharmacology* Free Radical Scavengers / metabolism* Hydrogen Peroxide / toxicity Inhibitory Concentration 50 Lipid Peroxidation / drug effects Plant Extracts / chemistry, pharmacology Plant Leaves / chemistry, metabolism Plants, Medicinal / chemistry*, metabolism Reactive Oxygen Species / metabolism Species Specificity Tea / chemistry*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Flavonoids; 0/Free Radical Scavengers; 0/Plant Extracts; 0/Reactive Oxygen Species; 0/Tea; 154-23-4/Catechin; 7722-84-1/Hydrogen Peroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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