Document Detail


Comparative expression of androgen receptor in the testis and epididymal region of roosters (Gallus domesticus) and drakes (Anas platyrhynchos).
MedLine Citation:
PMID:  17900574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The androgen receptor (AR) mediates the physiological actions of androgens, which play a crucial role in the maintenance of male reproductive function and fertility. Although the AR distribution pattern is well established in mammalian reproductive organs, information about the AR expression in the testes and epididymal region of birds is still scarce. To better clarify the pattern of AR expression in the avian male tract, we investigated the expression and precise cellular distribution of AR in the testis and epididymal region of roosters and drakes. AR expression was investigated by immunohistochemistry and Western blotting. In the testis, AR was found restricted to the nuclei of Sertoli cells, Leydig cells and some myoid cells in both species. Within the epididymal region, AR was widely expressed in the epithelia of all segments, although with segment specific differences in intensity and cellular distribution. Stronger positivity for AR was found in the principal cells of the epididymal duct, followed by the rete testis epithelium and non-ciliated cells of the distal efferent ductules. Non-ciliated cells of the proximal efferent ductules epithelium showed the lowest immunostaining. Ciliated cells of both segments of the efferent ductules were negative for AR. The connective tissue of roosters presented fewer AR-positive cells when compared with drakes; despite the similar total number of cells in both species. In conclusion, cellular and segment specific differences in AR expression suggest difference in sensitivity to androgens among the ducts composing the epididymal region of roosters and drakes.
Authors:
Rubem A P Dornas; André G Oliveira; Mariana O Dias; Germán A B Mahecha; Cleida A Oliveira
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-25
Journal Detail:
Title:  General and comparative endocrinology     Volume:  155     ISSN:  0016-6480     ISO Abbreviation:  Gen. Comp. Endocrinol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-11     Completed Date:  2008-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370735     Medline TA:  Gen Comp Endocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  773-9     Citation Subset:  IM    
Affiliation:
Department of Morphology, Federal University of Minas Gerais, Av. Antônio Carlos, 6627, Cx. Postal 486, CEP 31270-901, Belo Horizonte, MG, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blotting, Western
Chickens / metabolism*
Connective Tissue / metabolism
Ducks / metabolism*
Epididymis / metabolism*
Male
Receptors, Androgen / metabolism
Testis / metabolism*
Tissue Distribution
Chemical
Reg. No./Substance:
0/Receptors, Androgen

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