Document Detail


Comparative experimental antibacterial activity of ceftriaxone (Ro 13-9904).
MedLine Citation:
PMID:  6100173     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The in vitro activity of new cephalosporins, oxacephems and penicillins against pathogens involved in respiratory and gastrointestinal tract infections is practically equivalent. However, in experimental infections with the same pathogens the superior efficacy of ceftriaxone over all comparative cephems and penicillins, expressed in low 50% effective doses after multiple and particularly after single dosage schedules, and caused by a longer maintenance of blood and tissue levels can be demonstrated. Although mice have an altered pharmacokinetics these experimental results reflect the observed clinical advantage of ceftriaxone in human infections: long plasma half-life, low dosage and single daily administration.
Authors:
E Böhni
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Chemioterapia : international journal of the Mediterranean Society of Chemotherapy     Volume:  3     ISSN:  0392-906X     ISO Abbreviation:  Chemioterapia     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1985-08-07     Completed Date:  1985-08-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8401667     Medline TA:  Chemioterapia     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  25-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / pharmacology
Bacteria / drug effects*
Cefotaxime / analogs & derivatives*,  metabolism,  pharmacology,  therapeutic use
Ceftriaxone
Dose-Response Relationship, Drug
Haemophilus Infections / drug therapy
Metabolic Clearance Rate
Mice
Microbial Sensitivity Tests
Salmonella Infections / drug therapy
Streptococcal Infections / drug therapy
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 63527-52-6/Cefotaxime; 73384-59-5/Ceftriaxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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