Document Detail

Comparative evaluation of the safety of poly- and and oligoguanidines
MedLine Citation:
PMID:  17078303     Owner:  NLM     Status:  MEDLINE    
The antimicrobial activity and microenvironmental safety of poly- and oligoguanidine antiseptics were compared. E. coli and St. aureus test strains were found to be more sensitive to chlorohexidine bigluconate (CHB) upon a long (24 hour) exposure and to polyhexamethylene guanidine derivatives on short (30-second) contact. It is concluded that unlike polyguanidine antiseptics, CHB is more ecologically dangerous; when used for rapid disinfection, it can provoke impairment in the microenvironmental balance outside the area of application. The findings show it expedient to assess the microenvironmental safety of antimicrobial agents in order to prevent ecological catastrophes.
M Iu Timofeeva; G P Matiushina; I I Krasniuk; G I Rumiantsev; A A Vorob'ev; Iu V Nesvizhskiĭ; E A Bogdanova
Publication Detail:
Type:  English Abstract; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Gigiena i sanitariia     Volume:  -     ISSN:  0016-9900     ISO Abbreviation:  Gig Sanit     Publication Date:    2006 Jul-Aug
Date Detail:
Created Date:  2006-11-02     Completed Date:  2006-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0412700     Medline TA:  Gig Sanit     Country:  Russia (Federation)    
Other Details:
Languages:  rus     Pagination:  74-6     Citation Subset:  IM    
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MeSH Terms
Anti-Infective Agents / adverse effects*
Bacteria / drug effects
Environmental Pollution / adverse effects*
Guanidine / adverse effects*
Reg. No./Substance:
0/Anti-Infective Agents; 113-00-8/Guanidine

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