| Comparative evaluation of the safety of poly- and and oligoguanidines | |
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MedLine Citation:
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PMID: 17078303 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antimicrobial activity and microenvironmental safety of poly- and oligoguanidine antiseptics were compared. E. coli and St. aureus test strains were found to be more sensitive to chlorohexidine bigluconate (CHB) upon a long (24 hour) exposure and to polyhexamethylene guanidine derivatives on short (30-second) contact. It is concluded that unlike polyguanidine antiseptics, CHB is more ecologically dangerous; when used for rapid disinfection, it can provoke impairment in the microenvironmental balance outside the area of application. The findings show it expedient to assess the microenvironmental safety of antimicrobial agents in order to prevent ecological catastrophes. |
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Authors:
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M Iu Timofeeva; G P Matiushina; I I Krasniuk; G I Rumiantsev; A A Vorob'ev; Iu V Nesvizhskiĭ; E A Bogdanova |
Publication Detail:
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Type: English Abstract; Evaluation Studies; Journal Article |
Journal Detail:
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Title: Gigiena i sanitariia Volume: - ISSN: 0016-9900 ISO Abbreviation: Gig Sanit Publication Date: 2006 Jul-Aug |
Date Detail:
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Created Date: 2006-11-02 Completed Date: 2006-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0412700 Medline TA: Gig Sanit Country: Russia (Federation) |
Other Details:
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Languages: rus Pagination: 74-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Infective Agents
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adverse effects* Bacteria / drug effects Environmental Pollution / adverse effects* Guanidine / adverse effects* Humans |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 113-00-8/Guanidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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