Document Detail


Comparative evaluation of the reticulocyte hemoglobin content assay when screening for iron deficiency in elderly anemic patients.
MedLine Citation:
PMID:  21808729     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The aim of this study was to evaluate sensitivity and specificity for reticulocyte hemoglobin content (CHr) compared to other hematimetric and biochemical iron parameters, in particular, mean corpuscular hemoglobin (MCH), when screening for iron deficiency in elderly anemic patients. Bone marrow staining negative for iron was used as the gold standard criterion for iron deficiency anemia (IDA). Sensitivity and specificity for CHr, soluble transferrin receptor (sTfR), soluble transferrin receptor/log ferritin (TfR-F index), ferritin, MCH, and transferrin saturation were determined. The best cut-off point for CHr was 30.5 pg corresponding to a sensitivity and specificity of 93% and 69% for IDA, respectively. For MCH, a sensitivity of 93% and a specificity of 86%, respectively, correspond to an optimal cut-off of 28.5 pg. Analysis of CHr was not superior to MCH with respect to sensitivity and specificity when screening for IDA in elderly anemic patients.
Authors:
Torbjörn Karlsson
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Publication Detail:
Type:  Journal Article     Date:  2011-07-27
Journal Detail:
Title:  Anemia     Volume:  2011     ISSN:  2090-1275     ISO Abbreviation:  Anemia     Publication Date:  2011  
Date Detail:
Created Date:  2011-08-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101536021     Medline TA:  Anemia     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  925907     Citation Subset:  -    
Affiliation:
Department of Hematology, Uppsala University Hospital, 751 85 Uppsala, Sweden.
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