| Comparative evaluation of the reticulocyte hemoglobin content assay when screening for iron deficiency in elderly anemic patients. | |
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MedLine Citation:
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PMID: 21808729 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The aim of this study was to evaluate sensitivity and specificity for reticulocyte hemoglobin content (CHr) compared to other hematimetric and biochemical iron parameters, in particular, mean corpuscular hemoglobin (MCH), when screening for iron deficiency in elderly anemic patients. Bone marrow staining negative for iron was used as the gold standard criterion for iron deficiency anemia (IDA). Sensitivity and specificity for CHr, soluble transferrin receptor (sTfR), soluble transferrin receptor/log ferritin (TfR-F index), ferritin, MCH, and transferrin saturation were determined. The best cut-off point for CHr was 30.5 pg corresponding to a sensitivity and specificity of 93% and 69% for IDA, respectively. For MCH, a sensitivity of 93% and a specificity of 86%, respectively, correspond to an optimal cut-off of 28.5 pg. Analysis of CHr was not superior to MCH with respect to sensitivity and specificity when screening for IDA in elderly anemic patients. |
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Authors:
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Torbjörn Karlsson |
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Publication Detail:
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Type: Journal Article Date: 2011-07-27 |
Journal Detail:
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Title: Anemia Volume: 2011 ISSN: 2090-1275 ISO Abbreviation: Anemia Publication Date: 2011 |
Date Detail:
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Created Date: 2011-08-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101536021 Medline TA: Anemia Country: Egypt |
Other Details:
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Languages: eng Pagination: 925907 Citation Subset: - |
Affiliation:
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Department of Hematology, Uppsala University Hospital, 751 85 Uppsala, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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