| Comparative evaluation of nasal blood flow and airflow in the decongestant response to oxymetazoline. | |
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MedLine Citation:
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PMID: 22289724 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Nasal blood flow (NBF) plays a crucial role in many physiological and pathological processes but its regulation and relation to other rhinological outcomes is poorly understood. OBJECTIVES: We measured nasal airway patency, nasal blood flow, and subjective and objective measures of decongestion and assessed their reproducibility and responsiveness. METHODS: 19 healthy adults attended twice. A dose-response curve was constructed using doubling doses of oxymetazoline of 25μg, 50μg, 100μg, and 200μg at 20 minute intervals. Peak nasal inspiratory flow (PNIF) and nasal airway resistance (NAR) were measured at baseline and after each successive dose, NBF using laser Doppler flowmetry at baseline, 50 μg and 200 μg and a decongestion visual analogue scale after the final dose. RESULTS: After the final dose of oxymetazoline, NBF decreased by a mean (95% CI, P value) of 139.6 (108.3-170.8, P < .001) units and 99.4 (68.1-130.7, P < .001) units, PNIF increased by 48.9 (22.0-75.8, P < .001) L.min-1 and 38.9 (12.0-65.8, P = .003) L.min-1, and NAR decreased by 0.1 (0.02-0.15, P < .001) Pa/s/cm(3) and 0.09 (0.02-0.15, P = .002) Pa.s.cm-3 at the first and second visits respectively. The area under the curve of decongestion was not significantly different between visits for each variable. The standardized response means for the decongestant response were as follows: NBF, 1.41; PNIF, 1.03; and NAR, 0.97. CONCLUSIONS: Nasal blood flow using laser Doppler flowmetry is a sensitive and reproducible outcome to decongestion with oxymetazoline, similar to nasal patency and symptoms. CLINICAL TRIALS REGISTRATION: www.clinicaltrials.gov (NCT 00487032). |
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Authors:
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Sriram Vaidyanathan; Peter Williamson; Brian Lipworth |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology Volume: 108 ISSN: 1534-4436 ISO Abbreviation: Ann. Allergy Asthma Immunol. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9503580 Medline TA: Ann Allergy Asthma Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 77-80 Citation Subset: IM |
Copyright Information:
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Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
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Asthma & Allergy Research Group, Centre of Cardiovascular and Lung Biology, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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