Document Detail

Comparative evaluation of a high lipase pancreatic enzyme preparation and a standard pancreatic supplement for treating exocrine pancreatic insufficiency in chronic pancreatitis.
MedLine Citation:
PMID:  8853261     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the efficacy and safety of two enzyme-containing preparations, Pancrease HL (Cilag) containing 25,000 units of lipase per capsule and Creon (Triosol) with 8000 units of lipase per capsule, in patients with chronic pancreatitis and exocrine insufficiency. DESIGN: The study is a monocentric open crossover prospective study including 25 patients entered from March 1993 to May 1994. PATIENTS: Chronic pancreatitis was alcohol-related in 23 patients, previous surgery was performed in 9, 16 had diabetes and all had steatorrhoea (fat balance > 10g/24h). METHODS: Patients were investigated during four periods of 2 weeks, each one corresponding to a new treatment regimen: Pancrease HL, 3 capsules/day or Creon, 9 capsules/day, with or without omeprazole 20 mg/day. Stools were collected on the last 3 days at the end of each period when the patients were on a standard diet with a fixed daily intake of 100 g fat/day. RESULTS: Faecal fat, protein and energy excretion did not differ when both preparations were compared at roughly pharmaceutically equivalent doses. No significant improvement in fat and protein absorption was observed when omeprazole was taken with the pancreatic enzymes. However, omeprazole treatment was associated with a marked decrease in the fat-protein content ratio, suggesting an improvement in the fat digestive process but a decrease in the efficiency of protein digestion. Drug safety was comparable in the four groups of treatment. CONCLUSION: Pancrease HL with high lipase activity provides effective pancreatic enzyme replacement therapy in patients with chronic pancreatitis at an appreciably lower number of capsules per day than with standard preparations.
M Delhaye; S Meuris; A C Gohimont; K Buedts; M Cremer
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  8     ISSN:  0954-691X     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-26     Completed Date:  1996-12-26     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  699-703     Citation Subset:  IM    
Medicosurgical Department of Gastroenterology, Erasme Hospital, Free University of Brussels, Belgium.
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MeSH Terms
Cross-Over Studies
Drug Administration Schedule
Drug Therapy, Combination
Exocrine Pancreatic Insufficiency / drug therapy*,  etiology
Gastrointestinal Agents / therapeutic use*
Lipase / therapeutic use*
Middle Aged
Omeprazole / therapeutic use
Pancreatic Extracts / therapeutic use*
Pancreatin / therapeutic use*
Pancreatitis / complications,  drug therapy*
Pancreatitis, Alcoholic / complications,  drug therapy*
Prospective Studies
Reg. No./Substance:
0/Gastrointestinal Agents; 0/Pancreatic Extracts; 53608-75-6/Pancrelipase; 73590-58-6/Omeprazole; 8049-47-6/Pancreatin; EC

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