Document Detail


Comparative evaluation of diclofenac and dexamethasone following strabismus surgery.
MedLine Citation:
PMID:  12051282     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To compare efficacy of topical diclofenac sodium 0.1% with dexamethasone 0.1% following strabismus surgery. METHODS: In this study, 58 patients undergoing strabismus surgery were evaluated. They were randomized into two groups: 29 patients received topical 0.1% diclofenac (Group A), and 29 patients received 0.1% dexamethasone (Group B) for 4 weeks. The baseline parameters were similar in both groups. At each visit comprehensive ocular examination was performed to record patient discomfort, conjunctival inflammation, gap, and intraocular pressure. Follow-up visits were at 1 week, 2 weeks, and 4 weeks, postoperatively. RESULTS: There was no statistically significant difference in the rate of resolution of the inflammation, conjunctival healing, and intraocular pressure except rise of intraocular pressure at the fourth postoperative week in group B (P value <0.001). CONCLUSIONS: The results of this study suggest that diclofenac may be used as an alternative to dexamethasone after strabismus surgery.
Authors:
Subhash Dadeya; Kamlesh
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of pediatric ophthalmology and strabismus     Volume:  39     ISSN:  0191-3913     ISO Abbreviation:  J Pediatr Ophthalmol Strabismus     Publication Date:    2002 May-Jun
Date Detail:
Created Date:  2002-06-07     Completed Date:  2002-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7901143     Medline TA:  J Pediatr Ophthalmol Strabismus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  166-8     Citation Subset:  IM    
Affiliation:
Guru Nanak Eye Center, Maulana Azad Medical College, New Delhi, India.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Anti-Inflammatory Agents / therapeutic use*
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Dexamethasone / therapeutic use*
Diclofenac / therapeutic use*
Double-Blind Method
Humans
Inflammation / drug therapy
Intraocular Pressure / drug effects
Ophthalmic Solutions
Pain, Postoperative / drug therapy*
Prospective Studies
Random Allocation
Strabismus / surgery*
Treatment Outcome
Wound Healing / drug effects
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Ophthalmic Solutions; 15307-86-5/Diclofenac; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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