| Comparative evaluation of daptomycin (LY146032) and vancomycin in the treatment of experimental methicillin-resistant Staphylococcus aureus osteomyelitis in rabbits. | |
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MedLine Citation:
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PMID: 2546488 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A rabbit model for methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis was used to compare treatment with daptomycin, a new peptolide, and vancomycin. Daptomycin (4 mg/kg) and vancomycin (40 mg/kg) were injected subcutaneously every 12 and 6 h, respectively. After treatment, MRSA was found in bone cultures from 18 of 18 control rabbits, 10 of 17 animals treated with daptomycin, and 11 of 18 animals treated with vancomycin. Drug concentrations were measured in serum, uninfected bone, and infected bone 1 h after daptomycin or vancomycin was injected in a group of rabbits that had been infected for 3 to 4 weeks. Vancomycin was present at the highest concentrations in infected and uninfected bone. The results of this study suggest that daptomycin was similar to vancomycin in the eradication of MRSA from infected bone in an experimental model of osteomyelitis. |
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Authors:
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J T Mader; K Adams |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: 33 ISSN: 0066-4804 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 1989 May |
Date Detail:
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Created Date: 1989-08-25 Completed Date: 1989-08-25 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 689-92 Citation Subset: IM |
Affiliation:
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Marine Biomedical Institute, University of Texas Medical Branch, Galveston 77550-2772. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / pharmacokinetics, therapeutic use* Body Weight / drug effects Bone and Bones / microbiology Daptomycin Female Methicillin / pharmacology Osteomyelitis / drug therapy*, microbiology Penicillin Resistance Peptides / pharmacokinetics, therapeutic use Rabbits Staphylococcal Infections / drug therapy*, microbiology Staphylococcus aureus Vancomycin / pharmacokinetics, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Peptides; 103060-53-3/Daptomycin; 1404-90-6/Vancomycin; 61-32-5/Methicillin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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