Document Detail

Comparative evaluation of corneal epithelial permeability after the use of diclofenac 0.1% and flurbiprofen 0.03% after phacoemulsification.
MedLine Citation:
PMID:  11566521     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the corneal epithelial function after prolonged topical administration of diclofenac 0.1% and flurbiprofen 0.03% single-dose eyedrops. SETTING: University Eye Clinic of Trieste, Trieste, Italy. METHODS: This randomized prospective study comprised 24 patients scheduled for phacoemulsification. The patients were randomly assigned to receive diclofenac or flurbiprofen eyedrops for 2 months after surgery. Corneal epithelial permeability was determined by fluorophotometry 7, 37, and 67 days after surgery. RESULTS: An increase in corneal epithelial permeability was observed in the diclofenac group 37 and 67 days after surgery. No epithelial function alterations occurred in the flurbiprofen group. CONCLUSIONS: Subclinical impairment of the epithelial function was observed during topical treatment with diclofenac 0.1% single-dose eyedrops after phacoemulsification. The mechanism responsible for this effect remains unknown.
D Tognetto; P Cecchini; G Sanguinetti; M Pedio; G Ravalico
Publication Detail:
Type:  Clinical Trial; Comparative Study; Evaluation Studies; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of cataract and refractive surgery     Volume:  27     ISSN:  0886-3350     ISO Abbreviation:  J Cataract Refract Surg     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-21     Completed Date:  2001-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8604171     Medline TA:  J Cataract Refract Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1392-6     Citation Subset:  IM    
Eye Clinic, University of Trieste, Trieste, Italy.
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MeSH Terms
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics*
Cornea / metabolism*
Diclofenac / pharmacokinetics*
Epithelial Cells / metabolism*
Fluorescein / metabolism
Flurbiprofen / pharmacokinetics*
Lens Implantation, Intraocular
Middle Aged
Ophthalmic Solutions
Prospective Studies
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Ophthalmic Solutions; 15307-86-5/Diclofenac; 2321-07-5/Fluorescein; 5104-49-4/Flurbiprofen

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