Document Detail


Comparative electrophysiological effects of the antidepressants fluvoxamine and amitriptyline in the canine heart after myocardial infarction.
MedLine Citation:
PMID:  8832585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effects of fluvoxamine and amitriptyline on epicardial activation delay of premature excitations, the effective refractory period, and the incidence of ventricular arrhythmias by programmed electrical ventricular stimulation in the canine heart after myocardial infarction. Additionally, we investigated whether the inhibition of norepinephrine reuptake by amitriptyline contributes to epicardial activation delay or arrhythmias by combination with propranolol pretreatment. Amitriptyline, at a dose of 3 mg/kg, significantly prolonged epicardial activation delay of premature excitations in the infarcted zone in a frequency-dependent manner (n = 10). Amitriptyline also prolonged epicardial activation delay of premature excitations in the normal zone (n = 10). The effective refractory period in the infarcted zone was significantly prolonged by amitriptyline at a dose of 3 mg/kg (n = 8). Amitriptyline increased the incidence of ventricular arrhythmias induced by programmed electrical ventricular stimulation (n = 8). Propranolol did not affect the epicardial activation delay caused by amitriptyline or the incidence of ventricular arrhythmias induced by programmed electrical ventricular stimulation (n = 6). Fluvoxamine, on the other hand, had no significant effect on epicardial activation delay of premature excitations (n = 10) or the effective refractory period (n = 8) in both the infarcted and normal zones. Fluvoxamine did not increase the incidence of ventricular arrhythmias induced by programmed electrical ventricular stimulation (n = 8).
Authors:
Y Ikeda; M Nishimoto; Y Shimazu; H Hashimoto; K Umemura; M Nakashima
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  354     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-12-11     Completed Date:  1996-12-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  30-7     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Hamamatsu University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amitriptyline / administration & dosage,  pharmacology*
Animals
Antidepressive Agents, Second-Generation / pharmacology*
Antidepressive Agents, Tricyclic / pharmacology*
Antihypertensive Agents / administration & dosage,  pharmacology
Dogs
Electrocardiography
Evoked Potentials / drug effects
Fluvoxamine / pharmacology*
Heart / drug effects*,  physiopathology
Myocardial Infarction / physiopathology*
Propranolol / administration & dosage,  pharmacology
Chemical
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 0/Antidepressive Agents, Tricyclic; 0/Antihypertensive Agents; 50-48-6/Amitriptyline; 525-66-6/Propranolol; 54739-18-3/Fluvoxamine

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