Document Detail

Comparative efficacy and safety of topical permethrin, topical ivermectin, and oral ivermectin in patients of uncomplicated scabies.
MedLine Citation:
PMID:  22960817     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ivermectin has opened a new era in the management of scabies as orally effective drug. However, topical route has been little explored for ivermectin.
AIMS: To compare the efficacy and safety of topical permethrin, oral ivermectin, and topical ivermectin in the treatment of uncomplicated scabies.
METHODS: This was an open-label, randomized, comparative, parallel clinical trial conducted in 315 patients, randomly allocated to 3 groups. First group received permethrin 5% cream as single application, second group received tablet ivermectin 200 mcg/kg as single dose, and third group received ivermectin 1% lotion as single application. All the patients received anti-histaminic for pruritus. The patients were followed up at intervals of 1, 2, 3, and 4 weeks. If there were no signs of cure, the same intervention was repeated at each follow up. Primary efficacy variable was clinical cure of lesions. Statistical analysis was done by chi square test and one way ANOVA test using SPSS version 12.
RESULTS: At the end of first week, cure rate was 74.8% in permethrin group, 30% in oral ivermectin group, and 69.3% in topical ivermectin group (P < 0.05). At the end of second week, cure rate was 99% in permethrin group, 63% in oral ivermectin group, and 100% in topical ivermectin group (P < 0.05). At the end of third week, 100% cure rate was observed in permethrin and topical ivermectin group while 99% in oral ivermectin group (P = 0.367). No serious adverse events were observed.
CONCLUSIONS: Permethrin and topical ivermectin were equally effective against scabies while oral ivermectin was significantly less effective up to 2 weeks. Topical ivermectin can be used as an alternative to permethrin.
Sunita B Chhaiya; Varsha J Patel; Jayendra N Dave; Dimple S Mehta; Hiral A Shah
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Indian journal of dermatology, venereology and leprology     Volume:  78     ISSN:  0973-3922     ISO Abbreviation:  Indian J Dermatol Venereol Leprol     Publication Date:    2012 Sep-Oct
Date Detail:
Created Date:  2012-09-10     Completed Date:  2013-03-22     Revised Date:  2013-06-13    
Medline Journal Info:
Nlm Unique ID:  7701852     Medline TA:  Indian J Dermatol Venereol Leprol     Country:  India    
Other Details:
Languages:  eng     Pagination:  605-10     Citation Subset:  IM    
Department of Pharmacology, C. U. Shah Medical College, Surendranagar, Gujarat, India.
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MeSH Terms
Administration, Cutaneous
Administration, Oral
Analysis of Variance
Antiparasitic Agents / administration & dosage*,  adverse effects
Chi-Square Distribution
Drug Therapy, Combination
Histamine H1 Antagonists / therapeutic use
Hydroxyzine / therapeutic use
Ivermectin / administration & dosage*,  adverse effects
Permethrin / administration & dosage*,  adverse effects
Scabies / drug therapy*
Time Factors
Young Adult
Reg. No./Substance:
0/Antiparasitic Agents; 0/Histamine H1 Antagonists; 52645-53-1/Permethrin; 68-88-2/Hydroxyzine; 70288-86-7/Ivermectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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