Document Detail


Comparative efficacy of pirmenol and procainamide in a drug-resistant population with ventricular tachycardia.
MedLine Citation:
PMID:  3654999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The acute antiarrhythmic properties of pirmenol were studied in 12 patients who failed clinical oral drug therapy with a history of a cardiac arrest or sustained ventricular tachycardia (VT). Programmed electrical stimulation studies were performed in ten men and two women with a mean age of 63 +/- 2 years. All patients had inducible ventricular tachycardia by programmed electrical stimulation when they were off all antiarrhythmic therapy. Patients were then tested on procainamide, 1000 mg, administered intravenously, and ventricular tachycardia could be provoked in nine of twelve patients. Pirmenol was given intravenously, 1.1 mg/kg bolus followed by 40 micrograms/kg/min over 40 minutes prior to drug testing. Pirmenol did not significantly change the baseline heart rate, blood pressure, or measured electrocardiographic values from control values. Ten of 12 patients were still inducible to ventricular tachycardia on pirmenol. Procainamide protected one of nine patients against VT induction. In patients still inducible on drug therapy, the VT rate was significantly slowed from 221 beats/min to 166 beats/min on pirmenol and to 200 beats/min on procainamide. The effects of this new antiarrhythmic agent were similar to procainamide in this drug-resistant study population.
Authors:
D S Miura; J Schwartz; B Laux; J Wynn; D Keefe; J C Somberg
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  27     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-11-10     Completed Date:  1987-11-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  481-6     Citation Subset:  IM    
Affiliation:
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.
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MeSH Terms
Descriptor/Qualifier:
Anti-Arrhythmia Agents / therapeutic use*
Drug Resistance
Electrocardiography
Electrophysiology
Female
Heart Conduction System / physiopathology
Humans
Male
Middle Aged
Piperidines / therapeutic use*
Procainamide / therapeutic use*
Refractory Period, Electrophysiological / drug effects
Tachycardia / drug therapy*,  physiopathology
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Piperidines; 51-06-9/Procainamide; 61477-94-9/pirmenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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