Document Detail


Comparative efficacy of pilocarpine, timolol and latanoprost in experimental models of glaucoma.
MedLine Citation:
PMID:  18200329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intraocular pressure (IOP)-lowering effects of investigational antiglaucoma drugs often need comparison with existing drugs, but detailed data showing comparative efficacy of antiglaucoma drugs with different mechanism of action has not been reported so far. This study was designed to establish baseline information of the IOP-lowering effect of three currently used antiglaucoma drugs in three experimental models in rabbits, so that they act as a benchmark for the efficacy evaluation of the future experimental antiglaucoma drugs. The IOP-lowering effect of single-drop application of pilocarpine, timolol and latanoprost was studied in normotensive, water loading and steroid-induced models of glaucoma in rabbits. The noncontact tonometer was used for the first time to estimate IOP in rabbits. The peak IOP-lowering effect of pilocarpine, timolol and latanoprost in normotensive rabbit eye was 18.23%, 20% and 22.56%, respectively. In water-loading model, the maximum protection against the rise in IOP was shown by latanoprost (40.27%), followed by timolol (31.39%) and pilocarpine (28.91%). In steroid-pretreated rabbit eyes, peak IOP-lowering effects of pilocarpine, timolol and latanoprost were 25.65%, 34.21% and 35.06%, respectively. Therefore, the latanoprost was found to be most effective in all three models followed by timolol and pilocarpine. The results of this study can be used for future preclinical investigations for the assessment of IOP-lowering activity of potential antiglaucoma drugs.
Authors:
S K Gupta; R Agarwal; N D Galpalli; S Srivastava; S S Agrawal; R Saxena
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Methods and findings in experimental and clinical pharmacology     Volume:  29     ISSN:  0379-0355     ISO Abbreviation:  Methods Find Exp Clin Pharmacol     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-01-17     Completed Date:  2008-05-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909595     Medline TA:  Methods Find Exp Clin Pharmacol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  665-71     Citation Subset:  IM    
Affiliation:
Delhi Institute of Pharmaceutical Sciences and Research, New Delhi, India. skgupta@icriindia.com
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / administration & dosage,  toxicity
Animals
Anterior Chamber / drug effects,  pathology,  physiopathology
Cholinergic Agonists / pharmacology,  therapeutic use
Conjunctival Diseases / chemically induced,  drug therapy
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical / methods
Female
Glaucoma / chemically induced,  drug therapy*,  physiopathology
Instillation, Drug
Intraocular Pressure / drug effects
Male
Ophthalmic Solutions / pharmacology,  therapeutic use
Pilocarpine / pharmacology,  therapeutic use*
Prednisolone / administration & dosage,  toxicity
Prostaglandins F, Synthetic / pharmacology,  therapeutic use*
Rabbits
Timolol / pharmacology,  therapeutic use*
Tonometry, Ocular / methods
Treatment Outcome
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Cholinergic Agonists; 0/Ophthalmic Solutions; 0/Prostaglandins F, Synthetic; 130209-82-4/latanoprost; 26839-75-8/Timolol; 50-24-8/Prednisolone; 92-13-7/Pilocarpine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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