Document Detail


Comparative efficacy evaluation of moxidectin gel and ivermectin paste against internal parasites of equines in Brazil.
MedLine Citation:
PMID:  9877068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 24 male and female equines of mixed breed, 10-20 months of age and naturally infected with internal parasites was utilized in a controlled test to evaluate the efficacy of a moxidectin 2% gel formulation at the dosage of 0.4 mg moxidectin per kg of live weight and an ivermectin 1.87% commercial paste formulation at the dosage 0.2 mg ivermectin per kg applied orally. Animals were allocated into three groups of eight horses each based on pre-treatment eggs per gram (EPG) counts and treatments were randomized among the groups. One group was kept as untreated controls. One animal in the moxidectin-treated group died before the end of the trial from a cause unrelated to treatment leaving a total of seven animals in this group. Fecal egg counts were performed three times post-treatment and the number of parasites remaining in each animal was determined. Statistical analyses using geometric means were performed at the 1% level of significance. Both moxidectin and ivermectin preparations reduced initial EPG from a mean of 1600 to 0 on Days 5, 7 and at the end of the trial on Day 14. Efficacy percentages of moxidectin and ivermectin against immature and adult nematodes were as follows: Trichostrongylus axei, Parascaris equorum, Strongylus edentatus, S. vulgaris, Triodontophorus spp. and Gyalocephalus capitatus, 100% for both products; Habronema muscae 99.5 and 99.6%, respectively, Strongyloides westeri, 100 and 99.2%, respectively; Oxyuris equi, 99.6 and 100%, respectively; small strongyles, 99.7% for both products. Of the latter, the most numerous were: Cylicocyclus insigne, Cylicostephanus longibursatus and Cyathostomum catinatum. No Gasterophilus nasalis were found in horses from either treated group, while two of eight control horses had infections with thisparasite. Moxidectin showed greater efficacy (84.9%) than ivermectin (67.8%) against Strongylus vulgaris larvae found in the mesenteric artery aneurisms, but the difference was not statistically significant. Total parasite counts for both treated groups were significantly lower (p<0.01) than in the non-treated group. No significant differences were noted between moxidectin and ivermectin. Efficacy against the 30 nematode species found in this study was very evident for both products. As expected, neither moxidectin nor ivermectin was effective in controlling the tapeworm Anoplocephala perfoliata. No adverse reactions were observed during the experimental period.
Authors:
A J Costa; O F Barbosa; F R Moraes; A H Acuña; U F Rocha; V E Soares; A C Paullilo; A Sanches
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Veterinary parasitology     Volume:  80     ISSN:  0304-4017     ISO Abbreviation:  Vet. Parasitol.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-02-08     Completed Date:  1999-02-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7602745     Medline TA:  Vet Parasitol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  29-36     Citation Subset:  IM    
Affiliation:
Centro de Pesquisas Parasitológicas - CPPAR, Faculdade de Ciências Agrárias e Veterinárias - UNESP, Jaboticabal, SP, Brazil. cppar@fcav.unesp.br
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MeSH Terms
Descriptor/Qualifier:
Animals
Anthelmintics / administration & dosage,  pharmacology,  therapeutic use*
Anti-Bacterial Agents
Brazil
Digestive System / parasitology
Feces / parasitology
Female
Horse Diseases / drug therapy,  parasitology*
Horses
Ivermectin / administration & dosage,  pharmacology,  therapeutic use*
Macrolides / administration & dosage,  pharmacology,  therapeutic use
Male
Nematoda / drug effects
Nematode Infections / drug therapy,  parasitology,  veterinary*
Parasite Egg Count / veterinary
Randomized Controlled Trials as Topic
Chemical
Reg. No./Substance:
0/Anthelmintics; 0/Anti-Bacterial Agents; 0/Macrolides; 51570-36-6/milbemycin; 70288-86-7/Ivermectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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