Document Detail

Comparative efficacy of coronary vasodilatory methods.
MedLine Citation:
PMID:  856754     Owner:  NLM     Status:  MEDLINE    
The relative efficacy and sequelae of several coronary vasodilator methods were compared in dogs. Maximal coronary vasodilation with least apparent side effect was achieved with infusion of adenosine triphosphate (ATP) at the rate of approximately 600 microng/minute (approximately 20 microng/kg/minute). This method increased conductance to 7 to 8 times control levels and may have fully depleted vasodilator reserve. Bolus injections of ATP or papaverine alone increased conductances three to four fold and approximated the effects of 15 seconds of occlusion of the circumflex coronary artery. Duration of effect was variable. Diatrizoate injections were somewhat less effective vasodilators and produced greater electrocardiographic and systemic effects. Bolus injections of mixtures of ATP and papaverine demonstrated additive effects, and increased conductance 5 to 6 times control levels. In further exploring the diagnostic value of vasodilatory redistribution of myocardial blood flow or appearance of collateral circulation as a sign of a hemodynamically significant stenosis, selective intracoronary infusion of ATP is a promising vasodilatory method.
J J Bookstein; C B Higgins
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative radiology     Volume:  12     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:    1977 Mar-Apr
Date Detail:
Created Date:  1977-06-11     Completed Date:  1977-06-11     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  121-7     Citation Subset:  IM    
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MeSH Terms
Adenosine Triphosphate / pharmacology*
Blood Pressure / drug effects
Coronary Circulation / drug effects*
Diatrizoate / pharmacology*
Heart / drug effects
Papaverine / pharmacology*
Vasodilator Agents / pharmacology*
Reg. No./Substance:
0/Vasodilator Agents; 117-96-4/Diatrizoate; 56-65-5/Adenosine Triphosphate; 58-74-2/Papaverine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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